Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Guanfacine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 2/20 | 0.40 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guanfacine SCHEMBL439689 | 0.99 | KMT2A (0.42) | KMT2AMAPK1ADRA2AMEN1LMNA | |
| Guanfacine SCHEMBL439707 | 0.94 | MAPK1 (0.42) | KMT2AMAPK1ADRA2AMEN1LMNA | |
| Guanfacine SCHEMBL439819 | 0.93 | MAPK1 (0.41) | KMT2AMAPK1ADRA2AMEN1LMNA | |
| Guanfacine SCHEMBL790262 | 0.92 | ALDH1A1 (0.39) | KMT2AMAPK1ADRA2AMEN1LMNA | |
| Guanfacine SCHEMBL439673 | 0.91 | KMT2A (0.43) | KMT2AMAPK1ADRA2AMEN1LMNA | |
| Guanfacine SCHEMBL437682 | 0.90 | MAPT (0.43) | KMT2AMAPK1ADRA2AMEN1LMNA | |
| Guanfacine SCHEMBL789222 | 0.90 | KMT2A (0.43) | KMT2AMAPK1ADRA2AMEN1LMNA | |
| Guanfacine SCHEMBL789122 | 0.88 | KMT2A (0.41) | KMT2AMAPK1ADRA2AMEN1LMNA | |
| Guanfacine SCHEMBL35094 | 0.86 | KMT2A (0.54) | KMT2AMAPK1ADRA2AMEN1LMNA | |
| Guanfacine SCHEMBL440269 | 0.85 | KMT2A (0.41) | KMT2AMAPK1ADRA2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616434-A1 | PRODRUGS OF GUANFACINE | Shire LLC (US) | 2013-07-24 | — | — | EP | claimed |
| WO-2012035346-A1 | PRODRUGS OF GUANFACINE | SHIRE, LLC (US) | 2012-03-22 | — | — | WO | claimed |
| US-20120065152-A1 | PRODRUGS OF GUANFACINE | SHIRE LLC (US) | 2012-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065152-A1 | PRODRUGS OF GUANFACINE | UGT1A6, GDA, UGT1A3 | ADRA2A 172/4885ADRA2B 344/4885ADRA2C 171/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.