Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 17/20 | 0.51 |
| ▸ | GPR183 | P32249 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1834906 | 0.90 | GPR119 (0.51) | GPR119GPR183KCNH2ABCB1ABCC1 | |
| SCHEMBL8066046 | 0.89 | GPR119 (0.53) | GPR119GPR183KCNH2ABCB1ABCC1 | |
| SCHEMBL1834757 | 0.87 | GPR119 (0.50) | GPR119GPR183KCNH2 | |
| SCHEMBL2247183 | 0.86 | GPR119 (0.49) | GPR119GPR183KCNH2 | |
| SCHEMBL2892011 | 0.85 | GPR119 (0.53) | GPR119GPR183KCNH2ABCB1ABCC1 | |
| SCHEMBL13534599 | 0.84 | GPR119 (0.51) | GPR119GPR183KCNH2ABCB1ABCC1 | |
| SCHEMBL14138942 | 0.83 | GPR119 (0.54) | GPR119GPR183KCNH2ABCB1ABCC1 | |
| SCHEMBL3218225 | 0.83 | GPR119 (0.47) | GPR119GPR183KCNH2ABCB1ABCC1 | |
| SCHEMBL13534607 | 0.82 | GPR119 (0.50) | GPR119GPR183KCNH2ABCB1ABCC1 | |
| SCHEMBL1922600 | 0.82 | GPR119 (0.52) | GPR119GPR183KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2321308-B9 | PIPERIDINE GPCR AGONISTS | PROSIDION LTD (GB) | 2012-08-08 | — | — | EP | disclosed |
| EP-2321308-B1 | PIPERIDINE GPCR AGONISTS | PROSIDION LTD (GB) | 2012-05-09 | — | — | EP | disclosed |
| WO-2010004346-A1 | PIPERIDINYL GPCR AGONISTS | PROSIDION LIMITED (GB) | 2010-01-14 | — | — | WO | disclosed |
| WO-2010004344-A1 | PIPERIDINE GPCR AGONISTS | PROSIDION LIMITED (GB) | 2010-01-14 | — | — | WO | disclosed |