Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.36 |
| ▸ | CHRNA10 | Q9GZZ6 | 2/20 | 0.36 |
| ▸ | CHRNA9 | Q9UGM1 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 4/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NOS3 | P29474 | 2/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | FDPS | P14324 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4400673 | 0.94 | NPC1 (0.45) | TAAR1NPC1POLBRAB9ASMN1; SMN2 | |
| SCHEMBL4401493 | 0.85 | CHRNA7 (0.46) | NPC1POLBRAB9ASMN1; SMN2CHRNA7 | |
| SCHEMBL13334053 | 0.84 | NPC1 (0.49) | NPC1POLBRAB9ASMN1; SMN2CHRNA7 | |
| SCHEMBL4400594 | 0.83 | NPC1 (0.42) | NPC1POLBRAB9ASMN1; SMN2CHRNA7 | |
| Bromide SCHEMBL3317318 | 0.83 | NPC1 (0.51) | NPC1POLBRAB9ASMN1; SMN2CHRNA7 | |
| SCHEMBL8015063 | 0.82 | NPC1 (0.45) | NPC1POLBRAB9ASMN1; SMN2KDM4E | |
| SCHEMBL4404758 | 0.81 | NPC1 (0.44) | NPC1POLBRAB9ASMN1; SMN2CHRNA7 | |
| SCHEMBL4404565 | 0.81 | NPC1 (0.62) | TAAR1NPC1POLBRAB9ASMN1; SMN2 | |
| Bromide SCHEMBL7251134 | 0.80 | NPC1 (0.48) | NPC1POLBRAB9ASMN1; SMN2KDM4E | |
| SCHEMBL13334261 | 0.79 | CHRNA7 (0.46) | NPC1POLBRAB9ASMN1; SMN2CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8178678-B2 | Bis-quaternary ammonium salts and methods for modulating neuronal nicotinic acetylcholine receptors | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2012-05-15 | — | — | US | disclosed |
| US-20100069432-A1 | Bis-Quaternary Ammonium Salts and Methods for Modulating Neuronal Nicotinic Acetylcholine Receptors | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2010-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069432-A1 | Bis-Quaternary Ammonium Salts and Methods for Modulating Neuronal Nicotinic Acetylcholine Receptors | CHRNA2, CHRNA5, CHRNA4 | TAAR1 55/4885NPC1 1844/4885POLB 3604/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.