Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA3 | P07451 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | CA4 | P22748 | 1/20 | 0.34 |
| ▸ | CA6 | P23280 | 1/20 | 0.34 |
| ▸ | CA5A | P35218 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1144821 | 0.88 | CNR2 (0.49) | LMNACNR2KMT2ATSHRCA12 | |
| SCHEMBL16167682 | 0.84 | LMNA (0.35) | LMNAADORA2AADORA2BCNR2KMT2A | |
| SCHEMBL1144834 | 0.83 | HSD17B2 (0.49) | LMNAKMT2ASMN1; SMN2TSHRCA12 | |
| SCHEMBL4402971 | 0.82 | ADORA2A (0.41) | LMNAADORA2AADORA2BKMT2ASMN1; SMN2 | |
| SCHEMBL31637404 | 0.72 | TSHR (0.44) | LMNACYP2C9TSHRCYP2C19ALDH1A1 | |
| SCHEMBL31637418 | 0.72 | PDE4D (0.45) | KMT2ASMN1; SMN2CYP2C9CYP2C19CA12 | |
| SCHEMBL12327904 | 0.70 | LMNA (0.69) | LMNACNR2KMT2ACYP3A4CYP1A2 | |
| SCHEMBL1145074 | 0.70 | HSD17B2 (0.47) | LMNAKMT2ASMN1; SMN2TSHRCA12 | |
| SCHEMBL1144379 | 0.70 | CA12 (0.45) | CNR2KMT2ATSHRCA12CA1 | |
| SCHEMBL1145053 | 0.69 | ADORA2A (0.41) | LMNAADORA2AADORA2BKMT2ACA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012056372-A1 | N1/N2-LACTAM ACETYL-CoA CARBOXYLASE INHIBITORS | PFIZER INC. (US) | 2012-05-03 | — | — | WO | disclosed |