Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.48 |
| ▸ | CHRNA10 | Q9GZZ6 | 3/20 | 0.48 |
| ▸ | CHRNA9 | Q9UGM1 | 3/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | APAF1 | O14727 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RAD52 | P43351 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | GGPS1 | O95749 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13267940 | 0.95 | CHRNA7 (0.53) | HDAC1CHRNA7CHRNA10CHRNA9HDAC4 | |
| SCHEMBL5298519 | 0.90 | HDAC1 (0.53) | HDAC1HDAC4APAF1LMNAALDH1A1 | |
| SCHEMBL12638121 | 0.89 | CHRNA7 (0.61) | HDAC1CHRNA7CHRNA10CHRNA9HDAC4 | |
| SCHEMBL5305648 | 0.89 | CHRNA7 (0.49) | HDAC1CHRNA7CHRNA10CHRNA9HDAC4 | |
| SCHEMBL5290862 | 0.88 | HDAC1 (0.55) | HDAC1HDAC4APAF1LMNAALDH1A1 | |
| Hydrochloric Acid SCHEMBL30330313 | 0.88 | HDAC1 (0.55) | HDAC1HDAC4APAF1MAPTLMNA | |
| Water SCHEMBL30259465 | 0.88 | HDAC1 (0.55) | HDAC1CHRNA7CHRNA10CHRNA9HDAC4 | |
| SCHEMBL5294637 | 0.87 | HDAC1 (0.57) | HDAC1HDAC4APAF1LMNAALDH1A1 | |
| SCHEMBL5302832 | 0.87 | HDAC1 (0.57) | HDAC1HDAC4APAF1LMNAALDH1A1 | |
| SCHEMBL5301408 | 0.87 | HDAC1 (0.57) | HDAC1HDAC4APAF1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8178678-B2 | Bis-quaternary ammonium salts and methods for modulating neuronal nicotinic acetylcholine receptors | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2012-05-15 | — | — | US | disclosed |
| US-20100069432-A1 | Bis-Quaternary Ammonium Salts and Methods for Modulating Neuronal Nicotinic Acetylcholine Receptors | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2010-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069432-A1 | Bis-Quaternary Ammonium Salts and Methods for Modulating Neuronal Nicotinic Acetylcholine Receptors | CHRNA2, CHRNA5, CHRNA4 | HDAC1 202/4885CHRNA7 7/4885CHRNA10 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.