Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 5/20 | 0.64 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | PLAU | P00749 | 2/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.50 |
| ▸ | F12 | P00748 | 1/20 | 0.50 |
| ▸ | NCF1 | P14598 | 1/20 | 0.50 |
| ▸ | NOS3 | P29474 | 1/20 | 0.50 |
| ▸ | NOS1 | P29475 | 1/20 | 0.50 |
| ▸ | NOS2 | P35228 | 1/20 | 0.50 |
| ▸ | BACE1 | P56817 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | PLG | P00747 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31357187 | 0.89 | CNR2 (0.70) | CNR2RAB9APLAUCYP2A6F12 | |
| SCHEMBL5084291 | 0.89 | CNR2 (0.70) | CNR2RAB9APLAUCYP2A6F12 | |
| Water SCHEMBL27550989 | 0.87 | CNR2 (0.68) | CNR2RAB9APLAUCYP2A6F12 | |
| SCHEMBL13475588 | 0.87 | CNR2 (0.68) | CNR2RAB9AMAPTMEN1KMT2A | |
| Silver SCHEMBL11452821 | 0.86 | CNR2 (0.55) | CNR2RAB9APLAUCYP2A6F12 | |
| SCHEMBL28091074 | 0.86 | CNR2 (0.55) | CNR2RAB9APLAUCYP2A6F12 | |
| Lithium Ion SCHEMBL29972760 | 0.86 | CNR2 (0.55) | CNR2RAB9APLAUCYP2A6F12 | |
| SCHEMBL287165 | 0.86 | RAB9A (0.56) | CNR2RAB9APLAUCYP2A6F12 | |
| SCHEMBL5357601 | 0.86 | CNR2 (0.54) | CNR2RAB9APLAUCYP2A6F12 | |
| SCHEMBL13475580 | 0.86 | CNR2 (0.55) | CNR2RAB9AMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 119 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110041257-B | Method for synthesizing indene spiro indene [1,2-c ] isoquinoline triketone compound | 河南师范大学 | 2021-08-03 | — | — | CN | claimed |
| CN-110105359-B | Method for synthesizing indene spiro isoindole [2,1-b ] isoquinoline triketone compound | 河南师范大学 | 2021-08-03 | — | — | CN | claimed |
| CN-108997339-B | Method for synthesizing isoindole [2,1-b ] isoquinoline-7-carboxylic ester compound | 河南师范大学 | 2021-01-29 | — | — | CN | claimed |
| CN-110305062-A | Substituted isoquinoline ketone compounds and its synthetic method and application | 广州医科大学 | 2019-10-08 | — | — | CN | claimed |
| CN-110183379-A | A kind of copper catalysis one kettle way prepares the synthetic method and application of C-4 sulfuryl substituted isoquinoline ketone compounds | 青岛科技大学 | 2019-08-30 | — | — | CN | claimed |
| CN-109734662-A | A kind of trifluoromethyl substituted-dihydro isoquinolinone derivatives and preparation method thereof | 郑州大学 | 2019-05-10 | — | — | CN | claimed |
| CN-108997339-A | A method of synthesis iso-indoles [2,1-b] isoquinolin -7- carboxylic acid ester compound | 河南师范大学 | 2018-12-14 | — | — | CN | claimed |
| CN-107021958-A | FXR receptor stimulating agents | 山东轩竹医药科技有限公司 | 2017-08-08 | — | — | CN | claimed |
| CN-106674109-A | Method for synthesizing anti-cancer inhibitor intermediate | 温州医科大学附属第二医院 | 2017-05-17 | — | — | CN | claimed |
| CN-105859617-A | Fluoroisoquinolone compound and synthesis method thereof | 叶芳 | 2016-08-17 | — | — | CN | claimed |
| CN-103025383-A | Compounds for the treatment of clostridium difficile-associated diseases | SUMMIT CORP PLC | 2013-04-03 | — | — | CN | claimed |
| CN-100558728-C | Calcitonin gene related peptide receptor antagonists | BRISTOL MYERS SQUIBB CO (US) | 2009-11-11 | — | — | CN | claimed |
| CN-1972929-A | Heterocyclic CGRP antagonists for the treatment of migraine | BRISTOL MYERS SQUIBB CO (US) | 2007-05-30 | — | — | CN | claimed |
| CN-1671711-A | Calcitonin gene related peptide receptor antagonists | BRISTOL MYERS SQUIBB CO (US) | 2005-09-21 | — | — | CN | claimed |
| CN-115260096-B | Method for synthesizing dihydroisoquinolinones based on carbon monoxide gas or carbon monoxide substitution source | 武汉大学 | 2024-04-09 | — | — | CN | disclosed |
| CN-115260096-B | Method for synthesizing dihydroisoquinolinones based on carbon monoxide gas or carbon monoxide substitution source | 武汉大学 | 2024-04-09 | — | — | CN | disclosed |
| CN-113748104-B | Isoquinolinones for inhibiting SSAO/VAP-1 and application thereof | 广东东阳光药业股份有限公司 | 2024-02-27 | — | — | CN | disclosed |
| CN-1520296-A | Amino nicotinate derivatives as glucokinase (GLK) modulators | — | 2004-08-11 | — | — | CN | disclosed |
| CN-1449443-A | Fungal cell wall synthetic genes | EISAI CO LTD (JP) | 2003-10-15 | — | — | CN | disclosed |
| EP-1300464-A1 | FUNGAL CELL WALL SYNTHESIS GENE | Eisai Co., Ltd. (JP) | 2003-04-09 | — | — | EP | disclosed |