Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.81 |
| ▸ | RECQL | P46063 | 1/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.65 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.49 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.47 |
| ▸ | PREP | P48147 | 2/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | STS | P08842 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3919189 | 0.95 | HPGD (0.77) | HPGDRECQLHSD17B10EPHX1PTPN2 | |
| SCHEMBL493585 | 0.94 | HPGD (0.91) | HPGDRECQLHSD17B10EPHX1PTPN2 | |
| SCHEMBL6544206 | 0.91 | HPGD (0.97) | HPGDRECQLHSD17B10EPHX1PTPN2 | |
| SCHEMBL3164197 | 0.89 | HPGD (1.00) | HPGDRECQLHSD17B10EPHX1PTPN2 | |
| SCHEMBL5425897 | 0.89 | HPGD (0.68) | HPGDRECQLHSD17B10EPHX1PTPN2 | |
| SCHEMBL43357 | 0.89 | HPGD (0.66) | HPGDRECQLHSD17B10EPHX1PTPN2 | |
| SCHEMBL31169952 | 0.88 | HPGD (0.70) | HPGDRECQLHSD17B10EPHX1PTPN2 | |
| SCHEMBL26125044 | 0.88 | HPGD (0.79) | HPGDRECQLHSD17B10EPHX1PREP | |
| SCHEMBL1158811 | 0.86 | HPGD (0.77) | HPGDRECQLHSD17B10EPHX1PREP | |
| SCHEMBL27145831 | 0.86 | HPGD (0.64) | HPGDRECQLHSD17B10EPHX1PTPN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2024354-A1 | 1- [ (4- [BENZOYL (METHYL) AMINO]-3- (PHENYL) BUTYL]AZETIDINE DERIVATIVES FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS 1 | Albireo AB (SE) | 2009-02-18 | — | — | EP | disclosed |
| WO-2007136324-A1 | 1- [ (4- [BENZOYL (METHYL) AMINO] -3- (PHENYL) BUTYL] AZETIDINE DERIVATIVES FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS 1 | ALBIREO AB (SE) | 2007-11-29 | — | — | WO | disclosed |