SCHEMBL440453

SCHEMBL440453

Nc1ccn(OC=O)c(=O)n1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE3A Q14432 3/20 0.35
FGFR1 P11362 3/20 0.35
PDE4D Q08499 1/20 0.35
SLC29A1 Q99808 1/20 0.35
LMNA P02545 4/20 0.34
THRB P10828 1/20 0.34
MTOR P42345 1/20 0.34
MDM2 Q00987 1/20 0.34
NCOA1 Q15788 1/20 0.34
NCOA3 Q9Y6Q9 1/20 0.34
SLC22A6 Q4U2R8 1/20 0.34
CACNA1F O60840 2/20 0.33
ALB P02768 2/20 0.33
MAPT P10636 2/20 0.33
CACNA1D Q01668 2/20 0.33
CACNA1S Q13698 2/20 0.33
CACNA1C Q13936 2/20 0.33
ALDH1A1 P00352 1/20 0.32
POLB P06746 1/20 0.32
DCK P27707 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27503114 0.78 FGFR1 (0.35) PDE3AFGFR1PDE4DSLC29A1LMNA
SCHEMBL1065338 0.78 FGFR1 (0.35) PDE3AFGFR1PDE4DSLC29A1LMNA
SCHEMBL176469 0.76 FGFR1 (0.34) PDE3AFGFR1PDE4DSLC29A1LMNA
SCHEMBL28515026 0.76 FGFR1 (0.34) PDE3AFGFR1PDE4DSLC29A1LMNA
SCHEMBL8910525 0.74 FGFR1 (0.36) PDE3AFGFR1PDE4DSLC29A1LMNA
SCHEMBL15798503 0.74 PDE3A (0.33) PDE3AFGFR1PDE4DSLC29A1LMNA
SCHEMBL5356639 0.74 FGFR1 (0.39) PDE3AFGFR1PDE4DSLC29A1LMNA
SCHEMBL8007933 0.73 FGFR1 (0.35) PDE3AFGFR1PDE4DSLC29A1LMNA
SCHEMBL1629582 0.73 FGFR1 (0.44) PDE3AFGFR1PDE4DSLC29A1LMNA
SCHEMBL7743127 0.73 FGFR1 (0.35) PDE3AFGFR1PDE4DSLC29A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 269 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240226328-A9 MODULATION OF GENE EXPRESSION FOR DISEASE TREATMENT DOGODAN THERAPEUTICS INC (US) 2024-07-11 US disclosed
US-12018250-B2 Compositions and methods for evading bacterial defense mechanisms FRED HUTCHINSON CANCER CENTER (US) 2024-06-25 US disclosed
US-20240158833-A1 Compositions and Methods for Labeling Modified Nucleotides in Nucleic Acids NEW ENGLAND BIOLABS, INC. (US) 2024-05-16 US disclosed
US-20240131188-A1 MODULATION OF GENE EXPRESSION FOR DISEASE TREATMENT DOGODAN THERAPEUTICS INC (US) 2024-04-25 US disclosed
US-20240076738-A1 Methods for Measuring Analytes in Cell Subpopulations Cleveland Cytometry Services Company (US) 2024-03-07 US disclosed
CN-115322995-B Action of DNA methyltransferase Dnmt2 in liver injury repair 华中农业大学 2024-02-13 CN disclosed
EP-4314331-A1 METHODS FOR CHARACTERIZING SKINS Mitra Bio Limited (GB) 2024-02-07 EP disclosed
EP-4294936-A1 COMPOSITIONS AND METHODS FOR LABELING MODIFIED NUCLEOTIDES IN NUCLEIC ACIDS New England Biolabs, Inc. (US) 2023-12-27 EP disclosed
US-11827934-B2 Methods for isolating nucleic acids PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) 2023-11-28 US disclosed
US-11802289-B2 Transient silencing of ARGONAUTE1 and ARGONAUTE4 to increase recombinant protein expression in plants PLANTFORM CORPORATION (CA) 2023-10-31 US disclosed
EP-0193413-B1 Cloning restriction and modification genes NEW ENGLAND BIOLABS INC (US) 1993-12-22 EP disclosed
US-5215906-A Isolated DNA codes for producing endonuclease and methylase; culture product; genetic enginering NEW ENGLAND BIOLABS, INC. (US) 1993-06-01 US disclosed
US-5208157-A Cloning the TaqI restriction and modification genes NEW ENGLAND BIOLABS, INC. (US) 1993-05-04 US disclosed
US-5198354-A Genetic engineering NEW ENGLAND BIOLABS, INC. (US) 1993-03-30 US disclosed
US-5196331-A Genetic engineering NEW ENGLAND BIOLABS, INC. (US) 1993-03-23 US disclosed
US-5196332-A HAE-Haemophilus aegyptius NEW ENGLAND BIOLABS, INC. (US) 1993-03-23 US disclosed
US-5180673-A Cloning restriction and modification genes NEW ENGLAND BIOLABS, INC. (US) 1993-01-19 US disclosed
US-5137823-A METHOD FOR PRODUCING THE BAMHI RESTRICTION ENDONUCLEASE AND METHYLASE NEW ENGLAND BIOLABS, INC. (US) 1992-08-11 US disclosed
EP-0248678-A2 Method for cloning restriction modification system NEW ENGLAND BIOLABS, INC. (US) 1987-12-09 EP disclosed
EP-0193413-A2 Cloning restriction and modification genes NEW ENGLAND BIOLABS, INC. (US) 1986-09-03 EP disclosed