Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.78 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.71 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.71 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.71 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.71 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.71 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.71 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.71 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.71 |
| ▸ | EPHX1 | P07099 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | HPGD | P15428 | 4/20 | 0.58 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8013586 | 0.98 | SMN1; SMN2 (0.81) | SMN1; SMN2HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL7693790 | 0.92 | SMN1; SMN2 (0.77) | SMN1; SMN2HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL25825789 | 0.92 | SMN1; SMN2 (0.77) | SMN1; SMN2HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL38658755 | 0.92 | SMN1; SMN2 (0.91) | SMN1; SMN2HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL7699918 | 0.90 | SMN1; SMN2 (0.67) | SMN1; SMN2HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL9337868 | 0.90 | SMN1; SMN2 (0.95) | SMN1; SMN2HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL28668503 | 0.90 | SMN1; SMN2 (0.95) | SMN1; SMN2HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL15480466 | 0.87 | SMN1; SMN2 (0.81) | SMN1; SMN2HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL15480396 | 0.85 | HDAC1 (0.96) | SMN1; SMN2HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL6549000 | 0.85 | SMN1; SMN2 (0.84) | SMN1; SMN2HDAC3HDAC1HDAC2HDAC10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632911-B2 | Liquid modified diphenylmethane diisocyanates | BAYER MATERIALSCIENCE LLC (US) | 2009-12-15 | — | — | US | claimed |
| WO-2008060411-A2 | NEW LIQUID MODIFIED DIPHENYLMETHANE DIISOCYANATES | BAYER MATERIALSCIENCE LLC (US) | 2008-05-22 | — | — | WO | claimed |
| US-20080114186-A1 | New liquid modified diphenylmetilane diisocyanates | BAYER MATERIALSCIENCE LLC | 2008-05-15 | — | — | US | claimed |
| US-7632911-B2 | Liquid modified diphenylmethane diisocyanates | BAYER MATERIALSCIENCE LLC (US) | 2009-12-15 | — | — | US | disclosed |
| WO-2008060411-A2 | NEW LIQUID MODIFIED DIPHENYLMETHANE DIISOCYANATES | BAYER MATERIALSCIENCE LLC (US) | 2008-05-22 | — | — | WO | disclosed |
| US-20080114186-A1 | New liquid modified diphenylmetilane diisocyanates | BAYER MATERIALSCIENCE LLC | 2008-05-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080114186-A1 | New liquid modified diphenylmetilane diisocyanates | DDT, DIMT1, QDPR | SMN1; SMN2 3226/4885HDAC3 2793/4885HDAC1 2770/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.