Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Stavudine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALB | P02768 | 4/20 | 0.66 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | POLG | P54098 | 1/20 | 0.47 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.44 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.44 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.44 |
| ▸ | TK1 | P04183 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 10/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Stavudine SCHEMBL4773402 | 0.86 | ALB (0.64) | ALBLMNAALDH1A1POLBADRA1A | |
| Stavudine SCHEMBL28086387 | 0.86 | ALB (0.64) | ALBLMNAALDH1A1POLBADRA1A | |
| Emtricitabine SCHEMBL28148614 | 0.81 | ALB (0.95) | ALBLMNAPOLGCACNA1FMAPT | |
| Emtricitabine SCHEMBL12202574 | 0.81 | ALB (1.00) | ALBLMNAPOLGCACNA1FMAPT | |
| Emtricitabine SCHEMBL39708 | 0.81 | ALB (1.00) | ALBLMNAPOLGCACNA1FMAPT | |
| Emtricitabine SCHEMBL22413085 | 0.81 | ALB (1.00) | ALBLMNAPOLGCACNA1FMAPT | |
| Emtricitabine SCHEMBL6903677 | 0.81 | ALB (1.00) | ALBLMNAPOLGCACNA1FMAPT | |
| Emtricitabine SCHEMBL3722124 | 0.81 | ALB (1.00) | ALBLMNAPOLGCACNA1FMAPT | |
| Emtricitabine SCHEMBL5427218 | 0.81 | ALB (1.00) | ALBLMNAPOLGCACNA1FMAPT | |
| Emtricitabine SCHEMBL267686 | 0.81 | ALB (1.00) | ALBLMNAPOLGCACNA1FMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137214-A1 | NOVEL HUMAN ANTI-R7V ANTIBODIES AND USES THEREOF | URRMA R & D (FR) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008113833-A1 | NOVEL HUMAN ANTI-R7V ANTIBODIES AND USES THEREOF | URRMA R & D (FR) | 2008-09-25 | — | — | WO | disclosed |