Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Stavudine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALB | P02768 | 4/20 | 0.64 |
| ▸ | LMNA | P02545 | 3/20 | 0.64 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.64 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.64 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.64 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.57 |
| ▸ | BLM | P54132 | 1/20 | 0.57 |
| ▸ | POLG | P54098 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 8/20 | 0.39 |
| ▸ | TK2 | O00142 | 1/20 | 0.39 |
| ▸ | TK1 | P04183 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Stavudine SCHEMBL4773402 | 1.00 | ALB (0.64) | ALBLMNACACNA1FMAPTCACNA1D | |
| Didanosine SCHEMBL23925471 | 0.86 | ALB (0.50) | ALBLMNACACNA1FMAPTCACNA1D | |
| Stavudine SCHEMBL4405002 | 0.86 | ALB (0.66) | ALBLMNACACNA1FMAPTCACNA1D | |
| Lamivudine SCHEMBL22364335 | 0.86 | ALB (0.65) | ALBLMNACACNA1FMAPTCACNA1D | |
| Stavudine SCHEMBL7053412 | 0.86 | LMNA (0.60) | ALBLMNACACNA1FMAPTCACNA1D | |
| Stavudine SCHEMBL8185422 | 0.86 | LMNA (0.60) | ALBLMNACACNA1FMAPTCACNA1D | |
| Nevirapine SCHEMBL1898785 | 0.83 | LMNA (0.46) | ALBLMNACACNA1FMAPTCACNA1D | |
| Nevirapine SCHEMBL29379693 | 0.83 | LMNA (0.46) | ALBLMNACACNA1FMAPTCACNA1D | |
| Lamivudine SCHEMBL465678 | 0.80 | ALB (1.00) | ALBLMNACACNA1FMAPTCACNA1D | |
| Lamivudine SCHEMBL2422788 | 0.80 | ALB (1.00) | ALBLMNACACNA1FMAPTCACNA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103717597-B | Heterocyclic compounds as kinase inhibitors | 原真股份有限公司 | 2017-07-04 | — | — | CN | disclosed |
| CN-103492389-B | Pyrazolo [4,3-d] pyrimidine as inhibitors of kinases | 原真股份有限公司 | 2016-09-14 | — | — | CN | disclosed |