Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Isoleucine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 12/20 | 0.37 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 4/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.35 |
| ▸ | FAP | Q12884 | 2/20 | 0.35 |
| ▸ | NOS2 | P35228 | 2/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | PRCP | P42785 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isoleucine SCHEMBL27660748 | 1.00 | DPP4 (0.37) | DPP4DPP8DPP9DPP7FAP | |
| Isoleucine SCHEMBL6534831 | 0.95 | DPP4 (0.34) | DPP4DPP8DPP9DPP7FAP | |
| Isoleucine SCHEMBL1537322 | 0.95 | DPP4 (0.40) | DPP4DPP8DPP9DPP7FAP | |
| Isoleucine SCHEMBL1537321 | 0.95 | DPP4 (0.40) | DPP4DPP8DPP9DPP7FAP | |
| Isoleucine SCHEMBL28231733 | 0.95 | DPP4 (0.40) | DPP4DPP8DPP9DPP7FAP | |
| Isoleucine SCHEMBL138093 | 0.95 | DPP4 (0.40) | DPP4DPP8DPP9DPP7FAP | |
| Isoleucine SCHEMBL703839 | 0.95 | DPP4 (0.40) | DPP4DPP8DPP9DPP7FAP | |
| Isoleucine SCHEMBL1537461 | 0.95 | DPP4 (0.40) | DPP4DPP8DPP9DPP7FAP | |
| Isoleucine SCHEMBL1537458 | 0.95 | DPP4 (0.40) | DPP4DPP8DPP9DPP7FAP | |
| Isoleucine SCHEMBL5017800 | 0.95 | DPP4 (0.40) | DPP4DPP8DPP9DPP7FAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090143311-A1 | Compositions comprising tripeptides inhibiting ace | CONOPCO, INC. D/B/A UNILEVER | 2009-06-04 | — | — | US | disclosed |
| US-20090131331-A1 | Novel Nutraceutical Compositions | DSM IP ASSETS B.V. (NL) | 2009-05-21 | — | — | US | disclosed |
| EP-1881841-A1 | COMPOSITIONS COMPRISING TRIPEPTIDES INHIBITING ACE | UNILEVER N.V. (NL) | 2008-01-30 | — | — | EP | disclosed |
| WO-2006114195-A1 | COMPOSITIONS COMPRISING TRIPEPTIDES INHIBITING ACE | UNILEVER N.V. (NL) | 2006-11-02 | — | — | WO | disclosed |
| US-6777389-B1 | INHIBITING CUTANEOUS EFFECTS OF AGING | CONNECTIVE TISSUE IMAGINEERING LLC | 2004-08-17 | — | — | US | disclosed |