Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 8/20 | 0.36 |
| ▸ | HSD11B2 | P80365 | 2/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.32 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.32 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.32 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | STAT6 | P42226 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.32 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.32 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12861211 | 1.00 | PKM (0.37) | PKMHSD11B1HSD11B2EPHX2LMNA | |
| SCHEMBL75490 | 1.00 | PKM (0.37) | PKMHSD11B1HSD11B2EPHX2LMNA | |
| SCHEMBL256757 | 1.00 | PKM (0.37) | PKMHSD11B1HSD11B2EPHX2LMNA | |
| SCHEMBL10138542 | 1.00 | PKM (0.37) | PKMHSD11B1HSD11B2EPHX2LMNA | |
| SCHEMBL1154281 | 1.00 | PKM (0.37) | PKMHSD11B1HSD11B2EPHX2LMNA | |
| SCHEMBL3510056 | 1.00 | PKM (0.37) | PKMHSD11B1HSD11B2EPHX2LMNA | |
| SCHEMBL2812490 | 1.00 | PKM (0.37) | PKMHSD11B1HSD11B2EPHX2LMNA | |
| SCHEMBL974709 | 1.00 | PKM (0.37) | PKMHSD11B1HSD11B2EPHX2LMNA | |
| SCHEMBL13171860 | 1.00 | PKM (0.37) | PKMHSD11B1HSD11B2EPHX2LMNA | |
| SCHEMBL974708 | 1.00 | PKM (0.37) | PKMHSD11B1HSD11B2EPHX2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8344181-B2 | Obesity, type 2 diabetes, hyperlipidemia, hypertension, arteriosclerosis, coronary heart diseases | JANSSEN PHARMACEUTICA N.V. (BE) | 2013-01-01 | — | — | US | disclosed |
| EP-1796657-B1 | N-2 ADAMANTANYL-2-PHENOXY-ACETAMIDE DERIVATIVES AS 11-BETA HYDROXYSTEROID DEHYDROGENASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2009-12-23 | — | — | EP | disclosed |