Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CTSD | P07339 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL43241 | 0.88 | CES1 (0.58) | CES2CES1AKR1B1HSD11B1TDP1 | |
| Benzene SCHEMBL27614820 | 0.88 | CES1 (0.58) | CES2CES1AKR1B1HSD11B1TDP1 | |
| Methane SCHEMBL2442457 | 0.86 | CES1 (0.56) | CES2CES1AKR1B1HSD11B1TDP1 | |
| Water SCHEMBL27427566 | 0.86 | CES1 (0.56) | CES2CES1AKR1B1HSD11B1TDP1 | |
| SCHEMBL10999568 | 0.86 | CES1 (0.56) | CES2CES1AKR1B1HSD11B1TDP1 | |
| Benzene SCHEMBL27747096 | 0.86 | CES1 (0.56) | CES2CES1AKR1B1HSD11B1TDP1 | |
| Butane SCHEMBL11691843 | 0.84 | CES1 (0.54) | CES2CES1AKR1B1HSD11B1TDP1 | |
| Morpholine SCHEMBL28168698 | 0.83 | MAPT (0.42) | CES2CES1AKR1B1HSD11B1TDP1 | |
| Urea SCHEMBL6171504 | 0.82 | CES1 (0.52) | CES2CES1AKR1B1HSD11B1TDP1 | |
| Dimethylamine SCHEMBL3684568 | 0.82 | CES1 (0.52) | CES2CES1AKR1B1HSD11B1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117479932-A | Pyrazolone compounds for degenerative retinal diseases | 弗洛内克斯特(股份)责任有限公司 | 2024-01-30 | — | — | CN | claimed |
| CN-117479932-A | Pyrazolone compounds for degenerative retinal diseases | 弗洛内克斯特(股份)责任有限公司 | 2024-01-30 | — | — | CN | disclosed |
| EP-2138561-A1 | Stable aqueous surfactant compositions | Lubrizol Advanced Materials, Inc. (US) | 2009-12-30 | — | — | EP | disclosed |
| EP-1272159-B1 | STABLE AQUEOUS SURFACTANT COMPOSITIONS | LUBRIZOL ADVANCED MAT INC (US) | 2009-08-19 | — | — | EP | disclosed |
| US-7217752-B2 | Stable aqueous surfactant compositions | NOVEON, INC. (US) | 2007-05-15 | — | — | US | disclosed |
| US-20050158268-A1 | Stable aqueous surfactant compositions | NOVEON IP HOLDING CORP (US) | 2005-07-21 | — | — | US | disclosed |
| US-6897253-B2 | Stable aqueous surfactant compositions | NOVEON IP HOLDINGS CORP. (US) | 2005-05-24 | — | — | US | disclosed |
| CN-1195498-C | Directly compressed solid dosage particles | NOVEON IP HOLDINGS CORP (US) | 2005-04-06 | — | — | CN | disclosed |
| US-20040087668-A1 | Mixture containing alkali-soluble crosslinked poly(meth)acrylic acid; adding base to reduce pH; mixture containing cationic hair dye; storage stability | NOVEON IP HOLDINGS CORP. | 2004-05-06 | — | — | US | disclosed |
| CN-1471545-A | Rheology modifying copolymer composition | ŵ�ֶ�IP�عɹ�˾ | 2004-01-28 | — | — | CN | disclosed |
| EP-1276466-B1 | DIRECTLY COMPRESSED SOLID DOSAGE PARTICLES | NOVEON IP HOLDINGS CORP (US) | 2003-12-10 | — | — | EP | disclosed |
| US-6635702-B1 | Having crosslinked alkali swellable acrylate copolymer rheology modifier | NOVEON IP HOLDINGS CORP. | 2003-10-21 | — | — | US | disclosed |
| US-6623756-B1 | Controlled release tablet containing active ingredient, slightly crosslinked swellable polymer with good flow characteristics and excipients | NOVEON IP HOLDINGS CORP. | 2003-09-23 | — | — | US | disclosed |
| EP-1330477-A2 | RHEOLOGY MODIFYING COPOLYMER COMPOSITION | Noveon IP Holdings Corp. (US) | 2003-07-30 | — | — | EP | disclosed |
| CN-1426297-A | Directly compressed solid dosage formulations | NOVEON IP HOLDINGS CORP (US) | 2003-06-25 | — | — | CN | disclosed |
| EP-1272159-A2 | STABLE AQUEOUS SURFACTANT COMPOSITIONS | Noveon IP Holdings Corp. (US) | 2003-01-08 | — | — | EP | disclosed |
| US-6433061-B1 | CROSSLINKED COPOLYMER OF UNSATURATED CARBOXYLIC ACID, HYDROPHOBIC MONOMER, AND CHAIN TRANSFER AGENT; INCREASES VISCOSITY IN SALT-CONTAINING SYSTEMS; FOR USE IN SHAMPOOS, CLEANERS, AND DRUG DELIVERY SYSTEMS | NOVEON IP HOLDINGS CORP. | 2002-08-13 | — | — | US | disclosed |
| WO-2002034793-A2 | RHEOLOGY MODIFYING COPOLYMER COMPOSITION | NOVEON IP HOLDINGS CORP. (US) | 2002-05-02 | — | — | WO | disclosed |
| WO-2001076552-A2 | STABLE AQUEOUS SURFACTANT COMPOSITIONS | NOVEON IP HOLDINGS CORP. (US) | 2001-10-18 | — | — | WO | disclosed |