Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 5/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 5/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | TPH1 | P17752 | 4/20 | 0.36 |
| ▸ | TPH2 | Q8IWU9 | 2/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL988095 | 0.84 | CHEK2 (0.42) | KCNN4MAP4K4ACHECHEK2MKNK1 | |
| SCHEMBL986230 | 0.83 | KCNN4 (0.49) | KCNN4MAP4K4ACHE | |
| SCHEMBL984938 | 0.82 | KCNN4 (0.46) | KCNN4MAP4K4ACHE | |
| SCHEMBL988092 | 0.81 | KCNN4 (0.40) | KCNN4ACHE | |
| SCHEMBL4409316 | 0.81 | KCNN4 (0.37) | KCNN4ACHEMAPK1 | |
| SCHEMBL982686 | 0.81 | KCNN4 (0.38) | KCNN4MAP4K4ACHECHEK2MKNK1 | |
| SCHEMBL985022 | 0.81 | MAP4K4 (0.47) | KCNN4MAP4K4 | |
| SCHEMBL4405656 | 0.81 | PRCP (0.36) | KCNN4MAP4K4ACHEMAPK1 | |
| SCHEMBL988133 | 0.80 | MAPK1 (0.40) | KCNN4MAPK1 | |
| SCHEMBL983011 | 0.80 | KCNN4 (0.42) | KCNN4MAP4K4CHEK2MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004625-B1 | C-MET PROTEIN KINASE INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | VERTEX PHARMA (US) | 2009-12-30 | — | — | EP | claimed |