Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE8B | O95263 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | AHCY | P23526 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29551042 | 1.00 | PDE8B (0.42) | PDE8BATMMEN1KMT2AFKBP1A | |
| SCHEMBL29550324 | 1.00 | PDE8B (0.42) | PDE8BATMMEN1KMT2AFKBP1A | |
| SCHEMBL29318680 | 0.96 | MEN1 (0.42) | PDE8BATMMEN1KMT2AALDH1A1 | |
| SCHEMBL4843363 | 0.82 | PARP1 (0.37) | MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL4840050 | 0.82 | PARP1 (0.37) | MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL7203146 | 0.82 | PDE8B (0.46) | PDE8BATMKDM1AALDH1A1HSD17B10 | |
| SCHEMBL25867303 | 0.81 | PDE8B (0.47) | PDE8BATMKDM1AALDH1A1HSD17B10 | |
| SCHEMBL29550748 | 0.81 | MEN1 (0.41) | MEN1KMT2AFKBP1AALDH1A1HSD17B10 | |
| SCHEMBL29550782 | 0.81 | MEN1 (0.41) | MEN1KMT2AFKBP1AALDH1A1HSD17B10 | |
| SCHEMBL5940482 | 0.81 | MEN1 (0.41) | MEN1KMT2AFKBP1AALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8178535-B2 | Substituted sulfonamide compounds having bradykinin 1 receptor activity and use thereof as medicaments | GRUENENTHAL GMBH (DE) | 2012-05-15 | — | — | US | disclosed |
| US-20090203672-A1 | Substituted Sulfonamide Compounds | GRUENENTHAL GMBH (DE) | 2009-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090203672-A1 | Substituted Sulfonamide Compounds | RPS4X, RPS4Y1, CACNA1A | PDE8B 1544/4885ATM 2743/4885MEN1 2382/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.