Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 20/20 | 0.84 |
| ▸ | CNR2 | P34972 | 18/20 | 0.84 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.79 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.79 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.79 |
| ▸ | EGFR | P00533 | 1/20 | 0.79 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.79 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.79 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.79 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.79 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.79 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.79 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.79 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.79 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.70 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.70 |
| ▸ | HTR2A | P28223 | 1/20 | 0.70 |
| ▸ | HTR2C | P28335 | 1/20 | 0.70 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.70 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3619245 | 0.91 | CNR1 (1.00) | CNR1CNR2GABRA1ADRA2CSLC6A3 | |
| SCHEMBL13593624 | 0.90 | CNR1 (0.87) | CNR1CNR2GABRA1ADRA2CSLC6A3 | |
| Naphthyridinone SCHEMBL762298 | 0.89 | CNR1 (1.00) | CNR1CNR2GABRA1ADRA2CSLC6A3 | |
| SCHEMBL3622708 | 0.88 | CNR1 (1.00) | CNR1CNR2GABRA1ADRA2CSLC6A3 | |
| SCHEMBL3626355 | 0.87 | CNR1 (0.86) | CNR1CNR2GABRA1ADRA2CSLC6A3 | |
| SCHEMBL3624184 | 0.85 | CNR1 (0.83) | CNR1CNR2GABRA1ADRA2CSLC6A3 | |
| SCHEMBL4404582 | 0.84 | CNR1 (0.83) | CNR1CNR2GABRA1ADRA2CSLC6A3 | |
| SCHEMBL3616208 | 0.84 | CNR1 (0.91) | CNR1CNR2GABRA1ADRA2CSLC6A3 | |
| SCHEMBL12130118 | 0.83 | CNR1 (0.80) | CNR1CNR2GABRA1ADRA2CSLC6A3 | |
| SCHEMBL5315906 | 0.83 | CNR1 (0.76) | CNR1CNR2GABRA1ADRA2CSLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682550-B1 | SUBSTITUTED NAPHTHYRIDINONE DERIVATIVES | MERCK & CO INC (US) | 2009-12-23 | — | — | EP | claimed |