Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 2/20 | 0.53 |
| ▸ | CCND1 | P24385 | 2/20 | 0.53 |
| ▸ | CCND2 | P30279 | 2/20 | 0.53 |
| ▸ | CCND3 | P30281 | 2/20 | 0.53 |
| ▸ | CSF1R | P07333 | 4/20 | 0.51 |
| ▸ | DAPK1 | P53355 | 2/20 | 0.51 |
| ▸ | WEE1 | P30291 | 1/20 | 0.49 |
| ▸ | PAK1 | Q13153 | 3/20 | 0.49 |
| ▸ | PKN1 | Q16512 | 2/20 | 0.49 |
| ▸ | PAK4 | O96013 | 1/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.46 |
| ▸ | PAK3 | O75914 | 2/20 | 0.46 |
| ▸ | PAK2 | Q13177 | 2/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13593184 | 0.88 | SRC (0.57) | CSF1RDAPK1FGFR1LCKSRC | |
| SCHEMBL13593186 | 0.82 | SRC (0.58) | CSF1RDAPK1FGFR1LCKSRC | |
| SCHEMBL4466126 | 0.81 | CDK4 (0.53) | CDK4CCND1CCND2CCND3CSF1R | |
| SCHEMBL13593182 | 0.81 | SRC (0.54) | CSF1RDAPK1FGFR1LCKSRC | |
| SCHEMBL13593193 | 0.78 | FGFR1 (0.49) | FGFR1FGFR4 | |
| SCHEMBL4399224 | 0.77 | FGFR4 (0.41) | FGFR1SRCRIPK2ACVR1NOD2 | |
| SCHEMBL4331732 | 0.77 | FGFR1 (0.40) | FGFR1SRCRIPK2ACVR1NOD2 | |
| SCHEMBL13593197 | 0.76 | FGFR4 (0.55) | CSF1RDAPK1FGFR1LCKJAK2 | |
| SCHEMBL14381295 | 0.75 | SRC (0.45) | CSF1RDAPK1FGFR1LCKSRC | |
| SCHEMBL13593190 | 0.75 | SRC (0.48) | FGFR1SRCFGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090312321-A1 | COMPOSITIONS AND METHODS FOR FGF RECEPTOR KINASES INHIBITORS | IRM LLC (BM) | 2009-12-17 | — | — | US | disclosed |
| US-20090312321-A1 | COMPOSITIONS AND METHODS FOR FGF RECEPTOR KINASES INHIBITORS | IRM LLC (BM) | 2009-12-17 | — | — | US | disclosed |
| US-20090312321-A1 | COMPOSITIONS AND METHODS FOR FGF RECEPTOR KINASES INHIBITORS | IRM LLC (BM) | 2009-12-17 | — | — | US | disclosed |
| EP-2018167-A2 | COMPOSITIONS AND METHODS FOR FGF RECEPTOR KINASES INHIBITORS | IRM LLC (BM) | 2009-01-28 | — | — | EP | disclosed |
| WO-2007136465-A2 | COMPOSITIONS AND METHODS FOR FGF RECEPTOR KINASES INHIBITORS | IRM LLC (BM) | 2007-11-29 | — | — | WO | disclosed |
| WO-2007136465-A2 | COMPOSITIONS AND METHODS FOR FGF RECEPTOR KINASES INHIBITORS | IRM LLC (BM) | 2007-11-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090312321-A1 | COMPOSITIONS AND METHODS FOR FGF RECEPTOR KINASES INHIBITORS | PTK2B, SGK2, FRK | CDK4 477/4885CCND1 2912/4885CCND2 3019/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.