Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 17/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3970017 | 0.92 | HSD11B1 (0.68) | HSD11B1CYP2D6AVPR1AALDH1A1 | |
| SCHEMBL349521 | 0.85 | HSD11B1 (0.67) | HSD11B1CYP2D6AVPR1AALDH1A1 | |
| SCHEMBL349295 | 0.81 | HSD11B1 (0.85) | HSD11B1CYP2D6 | |
| SCHEMBL3971621 | 0.80 | HSD11B1 (0.69) | HSD11B1CYP2D6 | |
| SCHEMBL3967995 | 0.80 | HSD11B1 (0.59) | HSD11B1CYP2D6AVPR1A | |
| SCHEMBL3971584 | 0.79 | HSD11B1 (0.52) | HSD11B1CYP2D6AVPR1A | |
| SCHEMBL349442 | 0.79 | HSD11B1 (1.00) | HSD11B1CYP2D6 | |
| SCHEMBL349448 | 0.78 | HSD11B1 (0.60) | HSD11B1CYP2D6AVPR1AALDH1A1 | |
| SCHEMBL1322797 | 0.77 | HSD11B1 (0.73) | HSD11B1CYP2D6 | |
| SCHEMBL3972479 | 0.77 | HSD11B1 (0.56) | HSD11B1CYP2D6AVPR1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756063-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2009-03-25 | — | — | EP | claimed |
| EP-1756063-A1 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-02-28 | — | — | EP | claimed |
| WO-2005110992-A1 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2005-11-24 | — | — | WO | claimed |