Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 18/20 | 0.54 |
| ▸ | THRA | P10827 | 3/20 | 0.54 |
| ▸ | THRB | P10828 | 3/20 | 0.54 |
| ▸ | FTO | Q9C0B1 | 4/20 | 0.50 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.50 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.50 |
| ▸ | KDM6B | O15054 | 2/20 | 0.50 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.50 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.50 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5325511 | 0.88 | EGLN1 (0.61) | EGLN1THRATHRBFTOKDM5B | |
| SCHEMBL523085 | 0.86 | EGLN1 (0.57) | EGLN1THRATHRBFTOKDM5B | |
| SCHEMBL4413591 | 0.83 | EGLN1 (0.52) | EGLN1THRATHRBFTOKDM5B | |
| SCHEMBL4418148 | 0.82 | EGLN1 (0.52) | EGLN1THRATHRBFTOKDM5B | |
| SCHEMBL3924454 | 0.82 | EGLN1 (0.65) | EGLN1THRATHRBFTOBBOX1 | |
| SCHEMBL4414166 | 0.81 | EGLN1 (0.50) | EGLN1THRATHRBFTOKDM6B | |
| SCHEMBL4755239 | 0.81 | EGLN1 (0.58) | EGLN1THRATHRBFTOKDM5B | |
| SCHEMBL4407725 | 0.80 | EGLN1 (0.54) | EGLN1THRATHRBFTOKDM5B | |
| SCHEMBL522936 | 0.79 | EGLN1 (0.57) | EGLN1THRATHRBFTOKDM5B | |
| SCHEMBL27755809 | 0.79 | EGLN1 (0.50) | EGLN1THRATHRBFTOKDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008040002-A9 | METHODS, COMPOSITIONS AND ARTICLES OF MANUFACTURE FOR HIF MODULATING COMPOUNDS | HUTCHINSON FRED CANCER RES (US) | 2009-04-16 | — | — | WO | disclosed |
| WO-2008040002-A2 | METHODS, COMPOSITIONS AND ARTICLES OF MANUFACTURE FOR HIF MODULATING COMPOUNDS | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 2008-04-03 | — | — | WO | disclosed |