Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 14/20 | 0.52 |
| ▸ | FGFR2 | P21802 | 13/20 | 0.51 |
| ▸ | FGFR3 | P22607 | 13/20 | 0.51 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 4/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4408232 | 0.93 | FGFR1 (0.52) | FGFR1FGFR2FGFR3BTKMET | |
| SCHEMBL4406299 | 0.91 | BTK (0.43) | FGFR1FGFR2FGFR3BTKMET | |
| SCHEMBL4406089 | 0.90 | MET (0.42) | FGFR1FGFR2FGFR3BTKMET | |
| SCHEMBL4408976 | 0.88 | BTK (0.42) | FGFR1FGFR2FGFR3BTKMET | |
| SCHEMBL11946767 | 0.87 | FGFR1 (0.54) | FGFR1FGFR2FGFR3BTKMET | |
| SCHEMBL4407908 | 0.87 | JAK2 (0.44) | FGFR3BTKMETJAK2 | |
| SCHEMBL4407587 | 0.85 | MET (0.53) | MET | |
| SCHEMBL27918481 | 0.85 | MET (0.54) | BTKMET | |
| SCHEMBL4406161 | 0.85 | JAK2 (0.52) | FGFR3BTKMETJAK2 | |
| SCHEMBL984509 | 0.79 | BTK (0.45) | FGFR1FGFR2FGFR3BTKMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101479255-B | C-MET protein kinase inhibitors for the treatment of proliferative disorders | VERTEX PHARMA | 2013-05-01 | — | — | CN | claimed |
| EP-2004625-B1 | C-MET PROTEIN KINASE INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | VERTEX PHARMA (US) | 2009-12-30 | — | — | EP | claimed |
| US-20070254868-A1 | C-MET protein kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-11-01 | — | — | US | claimed |
| US-7872031-B2 | c-MET protein kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-01-18 | — | — | US | disclosed |
| US-7872031-B2 | c-MET protein kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-01-18 | — | — | US | disclosed |
| US-20070254868-A1 | C-MET protein kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-11-01 | — | — | US | disclosed |
| US-20070254868-A1 | C-MET protein kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-11-01 | — | — | US | disclosed |
| WO-2007111904-A2 | C-MET PROTEIN KINASE INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-10-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254868-A1 | C-MET protein kinase inhibitors | MET, PRKCH, ABL1 | FGFR1 285/4885FGFR2 323/4885FGFR3 249/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.