Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 16/20 | 0.40 |
| ▸ | BRAF | P15056 | 15/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4410213 | 0.93 | RAF1 (0.42) | RAF1BRAFMAPTCYP1A2CYP3A4 | |
| SCHEMBL14473015 | 0.91 | RAF1 (0.39) | RAF1BRAFMAPT | |
| SCHEMBL4565782 | 0.88 | BRAF (0.43) | RAF1BRAFMAPT | |
| SCHEMBL4410316 | 0.86 | RAF1 (0.43) | RAF1BRAFMAPTCYP1A2CYP3A4 | |
| SCHEMBL4552227 | 0.84 | RAF1 (0.44) | RAF1BRAF | |
| SCHEMBL4410934 | 0.84 | RAF1 (0.44) | RAF1BRAFCYP1A2CYP2C19 | |
| SCHEMBL5593338 | 0.84 | RAF1 (0.44) | RAF1BRAF | |
| SCHEMBL4408574 | 0.84 | RAF1 (0.44) | RAF1BRAF | |
| SCHEMBL4411086 | 0.83 | NR1H4 (0.46) | RAF1BRAFMAPT | |
| SCHEMBL4417829 | 0.83 | TEK (0.45) | RAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |