Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 16/20 | 0.44 |
| ▸ | BRAF | P15056 | 16/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4410934 | 0.90 | RAF1 (0.44) | RAF1BRAFHDAC3HDAC6MEN1 | |
| SCHEMBL4552227 | 0.90 | RAF1 (0.44) | RAF1BRAFHDAC3HDAC6 | |
| SCHEMBL5593338 | 0.90 | RAF1 (0.44) | RAF1BRAFHDAC3HDAC6TRPV1 | |
| SCHEMBL4411086 | 0.89 | NR1H4 (0.46) | RAF1BRAFMEN1KMT2ATRPV1 | |
| SCHEMBL4410316 | 0.89 | RAF1 (0.43) | RAF1BRAFHDAC3HDAC6 | |
| SCHEMBL4565782 | 0.89 | BRAF (0.43) | RAF1BRAFMEN1KMT2ATRPV1 | |
| SCHEMBL4565727 | 0.88 | NR1H4 (0.48) | RAF1BRAFHDAC6 | |
| SCHEMBL4410213 | 0.87 | RAF1 (0.42) | RAF1BRAF | |
| SCHEMBL4415077 | 0.87 | RAF1 (0.52) | RAF1BRAF | |
| SCHEMBL4417829 | 0.87 | TEK (0.45) | RAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007075896-A2 | HETEROCYCLIC CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007075896-A2 | HETEROCYCLIC CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-07-05 | — | — | WO | disclosed |