Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.30 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8898024 | 1.00 | TSHR (0.50) | TSHRLMNACHRM1AKR1A1CHRM3 | |
| SCHEMBL26104129 | 0.87 | TSHR (0.39) | TSHRSPHK1 | |
| SCHEMBL24653412 | 0.87 | TSHR (0.50) | TSHRLMNA | |
| SCHEMBL26102216 | 0.87 | TSHR (0.44) | TSHRSPHK1 | |
| SCHEMBL107471 | 0.86 | TSHR (0.42) | TSHRLMNA | |
| SCHEMBL9136335 | 0.86 | TSHR (0.48) | TSHRLMNA | |
| SCHEMBL14433121 | 0.84 | TSHR (0.59) | TSHRLMNATDP1SPHK1 | |
| SCHEMBL8534024 | 0.84 | TSHR (0.59) | TSHRLMNATDP1SPHK1 | |
| SCHEMBL5907165 | 0.84 | TSHR (0.59) | TSHRLMNATDP1SPHK1 | |
| SCHEMBL20677244 | 0.84 | GPR84 (0.48) | TSHRLMNASPHK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1609798-B1 | FUSED HETEROCYCLIC DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE SAME, AND MEDICINAL USE THEREOF | KISSEI PHARMACEUTICAL (JP) | 2012-05-09 | — | — | EP | disclosed |