SCHEMBL4408476

SCHEMBL4408476

Nc1ncc(C2=CC[N]CC2)cc1-c1nnnn1-c1cccc(F)c1F

nearest known ligand 0.40

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
KCNN4 O15554 20/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4406450 0.95 KCNN4 (0.39) KCNN4
SCHEMBL982751 0.85 KCNN4 (0.40) KCNN4
SCHEMBL985137 0.84 KCNN4 (0.46) KCNN4
SCHEMBL986511 0.84 KCNN4 (0.39) KCNN4
SCHEMBL985811 0.84 KCNN4 (0.39) KCNN4
SCHEMBL984387 0.84 KCNN4 (0.39) KCNN4
SCHEMBL985450 0.82 KCNN4 (0.46) KCNN4
SCHEMBL984938 0.82 KCNN4 (0.46) KCNN4
SCHEMBL984978 0.82 KCNN4 (0.50) KCNN4
SCHEMBL985675 0.81 CCNT1 (0.37) KCNN4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2004625-B1 C-MET PROTEIN KINASE INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS VERTEX PHARMA (US) 2009-12-30 EP claimed