Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 5/20 | 0.37 |
| ▸ | CDK9 | P50750 | 5/20 | 0.37 |
| ▸ | KCNN4 | O15554 | 5/20 | 0.37 |
| ▸ | GRM1 | Q13255 | 7/20 | 0.36 |
| ▸ | GRM5 | P41594 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL987228 | 0.96 | KCNN4 (0.35) | CCNT1CDK9KCNN4GRM1GRM5 | |
| SCHEMBL988378 | 0.92 | ERN1 (0.40) | CCNT1CDK9KCNN4GRM1GRM5 | |
| SCHEMBL987001 | 0.91 | ALDH1A1 (0.38) | CCNT1CDK9KCNN4GRM1GRM5 | |
| SCHEMBL986695 | 0.90 | NAMPT (0.41) | CCNT1CDK9KCNN4GRM1GRM5 | |
| SCHEMBL982752 | 0.90 | GRM1 (0.39) | CCNT1CDK9KCNN4GRM1GRM5 | |
| SCHEMBL985805 | 0.90 | NAMPT (0.39) | CCNT1CDK9KCNN4GRM1GRM5 | |
| SCHEMBL984594 | 0.89 | ERN1 (0.37) | CCNT1CDK9KCNN4GRM1GRM5 | |
| SCHEMBL987033 | 0.88 | CDK9 (0.39) | CCNT1CDK9KCNN4GRM1GRM5 | |
| SCHEMBL2076538 | 0.88 | GRM5 (0.51) | CCNT1CDK9GRM1GRM5 | |
| SCHEMBL984990 | 0.88 | NAMPT (0.38) | CCNT1CDK9KCNN4GRM1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7872031-B2 | c-MET protein kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-01-18 | — | — | US | claimed |