Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 16/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.47 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.47 |
| ▸ | RAF1 | P04049 | 16/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.45 |
| ▸ | FRK | P42685 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4565578 | 0.94 | RAF1 (0.46) | BRAFRAF1 | |
| SCHEMBL4407858 | 0.93 | RAF1 (0.55) | BRAFRAF1 | |
| SCHEMBL4412586 | 0.91 | RAF1 (0.46) | BRAFRAF1 | |
| SCHEMBL4417419 | 0.91 | GLA (0.48) | BRAFRAF1 | |
| SCHEMBL4411086 | 0.91 | NR1H4 (0.46) | NR1H4BRAFMAPK14RAF1EPHA3 | |
| SCHEMBL4412688 | 0.90 | RAF1 (0.45) | BRAFRAF1 | |
| SCHEMBL4408307 | 0.89 | RAF1 (0.42) | BRAFRAF1 | |
| SCHEMBL4551203 | 0.89 | CYP1A2 (0.45) | BRAFRAF1 | |
| SCHEMBL4565699 | 0.89 | BRAF (0.45) | BRAFMAPK14MAPK13KDRMAPK12 | |
| SCHEMBL4565940 | 0.88 | FFAR1 (0.46) | NR1H4BRAFMAPK14RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007075896-A2 | HETEROCYCLIC CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-07-05 | — | — | WO | disclosed |