Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.49 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 4/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9179488 | 0.85 | HPGD (0.42) | HPGDNOTUMKMT2ATDP1HTR7 | |
| SCHEMBL5873731 | 0.82 | HPGD (0.50) | HPGDNOTUMDDB1CRBNKMT2A | |
| SCHEMBL31726238 | 0.82 | HPGD (0.50) | HPGDNOTUMDDB1CRBNKMT2A | |
| SCHEMBL318501 | 0.78 | NOTUM (0.47) | HPGDNOTUMDDB1CRBNKMT2A | |
| SCHEMBL9036500 | 0.77 | MEN1 (0.47) | HPGDNOTUMKMT2ATDP1MEN1 | |
| SCHEMBL28669819 | 0.77 | HPGD (0.49) | HPGDNOTUMDDB1CRBNKMT2A | |
| SCHEMBL29765632 | 0.74 | HPGD (0.59) | HPGDNOTUMDDB1CRBNKMT2A | |
| SCHEMBL9954152 | 0.73 | HPGD (0.49) | HPGDNOTUMDDB1CRBNKMT2A | |
| SCHEMBL3641405 | 0.72 | HPGD (0.57) | HPGDNOTUMDDB1CRBNKMT2A | |
| SCHEMBL1464486 | 0.72 | HPGD (0.57) | HPGDNOTUMDDB1CRBNKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009135000-A2 | INHIBITION OF SHP2/PTPN11 PROTEIN TYROSINE PHOSPHATASE BY NSC-117199 AND ANALOGS | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2009-11-05 | — | — | WO | disclosed |
| WO-1993012786-A1 | INDOLINONE DERIVATIVES | HOWARD HARRY R JR (US) | 1993-07-08 | — | — | WO | disclosed |