Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.47 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.39 |
| ▸ | HTR7 | P34969 | 4/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31726238 | 1.00 | HPGD (0.50) | HPGDNOTUMDDB1CRBNKMT2A | |
| SCHEMBL21457751 | 0.84 | HPGD (0.38) | HPGDNOTUMKMT2AOPRM1OPRK1 | |
| SCHEMBL4409235 | 0.82 | HPGD (0.56) | HPGDNOTUMDDB1CRBNKMT2A | |
| SCHEMBL24049835 | 0.78 | HPGD (0.35) | HPGDNOTUMKMT2AOPRM1OPRK1 | |
| SCHEMBL318501 | 0.77 | NOTUM (0.47) | HPGDNOTUMDDB1CRBNKMT2A | |
| SCHEMBL28669819 | 0.75 | HPGD (0.49) | HPGDNOTUMDDB1CRBNKMT2A | |
| SCHEMBL6362724 | 0.74 | KMT2A (0.33) | HPGDNOTUMKMT2AMEN1MAPT | |
| SCHEMBL5323856 | 0.74 | HPGD (0.55) | HPGDNOTUMDDB1CRBNKMT2A | |
| SCHEMBL30215698 | 0.73 | HTR7 (0.50) | HPGDNOTUMCASP3HTR7HTR1A | |
| SCHEMBL185755 | 0.73 | HTR7 (0.50) | HPGDNOTUMCASP3HTR7HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111704571-A | Preparation method of optically active 2-aryl spiro [ cyclopentane-1, 3' -indole ] -3-formaldehyde | 南宁师范大学 | 2020-09-25 | — | — | CN | claimed |
| CN-111704571-A | Preparation method of optically active 2-aryl spiro [ cyclopentane-1, 3' -indole ] -3-formaldehyde | 南宁师范大学 | 2020-09-25 | — | — | CN | disclosed |
| CN-111704571-A | Preparation method of optically active 2-aryl spiro [ cyclopentane-1, 3' -indole ] -3-formaldehyde | 南宁师范大学 | 2020-09-25 | — | — | CN | disclosed |
| EP-1317013-B1 | NON-AQUEOUS ELECTROLYTE AND SECONDARY CELL USING THE SAME | MITSUBISHI CHEM CORP (JP) | 2017-03-15 | — | — | EP | disclosed |
| US-7129253-B2 | Compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-31 | — | — | US | disclosed |
| US-6942948-B2 | Nonaqueous electrolyte solution and secondary battery employing the same | MITSUBISHI CHEMICAL CORPORATION (JP) | 2005-09-13 | — | — | US | disclosed |
| US-20030165733-A1 | Nonaqueous electrolyte solution and secondary battery employing the same | MITSUBISHI CHEMICAL CORPORATION (JP) | 2003-09-04 | — | — | US | disclosed |
| EP-1317013-A1 | NON-AQUEOUS ELECTROLYTE AND SECONDARY CELL USING THE SAME | MITSUBISHI CHEMICAL CORPORATION (JP) | 2003-06-04 | — | — | EP | disclosed |
| US-6498176-B1 | INHIBITING TUMOR GROWTH VIA INHIBITION OF TUMOR-RELATED ANGIOGENESIS | SMITHKLINEBEECHAM CORPORATION | 2002-12-24 | — | — | US | disclosed |
| US-6358750-B1 | FOR COMBINATORIAL LIBRARIES; DRUG SCREENING | ARQULE, INC. | 2002-03-19 | — | — | US | disclosed |
| EP-1125937-A2 | Spiro [Pyrrolidine-2,3'-oxindole] compounds and methods of use | ARQULE, INC. (US) | 2001-08-22 | — | — | EP | disclosed |
| EP-1015430-A4 | SPIRO PYRROLIDINE-2,3'-OXINDOLE] COMPOUNDS AND METHODS OF USE | ARQULE INC (US) | 2001-01-17 | — | — | EP | disclosed |
| US-6114540-A | COMBINATORIAL LIBRARIES | ARQULE, INC. (US) | 2000-09-05 | — | — | US | disclosed |
| EP-1015430-A1 | SPIRO PYRROLIDINE-2,3'-OXINDOLE] COMPOUNDS AND METHODS OF USE | ARQULE, INC. (US) | 2000-07-05 | — | — | EP | disclosed |
| WO-1999012904-A1 | SPIRO[PYRROLIDINE-2,3'-OXINDOLE] COMPOUNDS AND METHODS OF USE | ARQULE, INC. (US) | 1999-03-18 | — | — | WO | disclosed |