Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.60 |
| ▸ | POLB | P06746 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.60 |
| ▸ | VCP | P55072 | 1/20 | 0.60 |
| ▸ | TLK2 | Q86UE8 | 3/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 7/20 | 0.43 |
| ▸ | NPC1 | O15118 | 6/20 | 0.43 |
| ▸ | GAA | P10253 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4409453 | 1.00 | MAPT (0.60) | MAPTL3MBTL1POLBMEN1KMT2A | |
| SCHEMBL4895008 | 0.92 | KMT2A (0.52) | MAPTL3MBTL1POLBMEN1KMT2A | |
| SCHEMBL4895014 | 0.92 | KMT2A (0.52) | MAPTL3MBTL1POLBMEN1KMT2A | |
| SCHEMBL4408999 | 0.90 | MEN1 (0.67) | MAPTL3MBTL1POLBMEN1KMT2A | |
| SCHEMBL4408992 | 0.90 | MEN1 (0.67) | MAPTL3MBTL1POLBMEN1KMT2A | |
| SCHEMBL14111968 | 0.89 | MAPT (0.49) | MAPTL3MBTL1POLBMEN1KMT2A | |
| SCHEMBL14111963 | 0.89 | POLB (0.48) | MAPTL3MBTL1POLBMEN1KMT2A | |
| SCHEMBL4412400 | 0.84 | PTPN6 (0.46) | MAPTL3MBTL1POLBMEN1KMT2A | |
| SCHEMBL4412396 | 0.84 | PTPN6 (0.46) | MAPTL3MBTL1POLBMEN1KMT2A | |
| SCHEMBL4897722 | 0.83 | POLB (0.47) | MAPTL3MBTL1POLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009135000-A2 | INHIBITION OF SHP2/PTPN11 PROTEIN TYROSINE PHOSPHATASE BY NSC-117199 AND ANALOGS | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2009-11-05 | — | — | WO | disclosed |