Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | AGXT | P21549 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4411606 | 1.00 | CA1 (0.41) | CA1CA2CA7CA9TSHR | |
| SCHEMBL4412607 | 0.89 | CA1 (0.43) | CA1CA2CA7CA9TSHR | |
| SCHEMBL537720 | 0.84 | CA1 (0.54) | CA1CA2CA7CA9TSHR | |
| SCHEMBL13595470 | 0.84 | CA1 (0.54) | CA1CA2CA7CA9TSHR | |
| SCHEMBL13595479 | 0.84 | CA1 (0.54) | CA1CA2CA7CA9TSHR | |
| SCHEMBL10587310 | 0.84 | CA1 (0.54) | CA1CA2CA7CA9TSHR | |
| SCHEMBL13108196 | 0.84 | CA1 (0.54) | CA1CA2CA7CA9TSHR | |
| SCHEMBL2420068 | 0.81 | CA1 (0.54) | CA1CA2CA7CA9TSHR | |
| SCHEMBL7450610 | 0.81 | CA1 (0.54) | CA1CA2CA7CA9TSHR | |
| SCHEMBL27391960 | 0.81 | CA1 (0.54) | CA1CA2CA7CA9TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8642644-B2 | Ophthamological drugs | DUKE UNIVERSITY (US) | 2014-02-04 | — | — | US | disclosed |
| US-20090318542-A1 | OPHTHAMOLOGICAL DRUGS | DUKE UNIVERSITY | 2009-12-24 | — | — | US | disclosed |
| EP-1812017-A2 | OPHTHAMOLOGICAL DRUGS | Duke University (US) | 2007-08-01 | — | — | EP | disclosed |
| US-20060135609-A1 | Ophthamological drugs | DUKE UNIVERSITY (US) | 2006-06-22 | — | — | US | disclosed |
| WO-2006047466-A2 | OPHTHAMOLOGICAL DRUGS | DUKE UNIVERSITY (US) | 2006-05-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060135609-A1 | Ophthamological drugs | QDPR, PTGIR, PDE6C | CA1 1914/4885CA2 148/4885CA7 241/4885 |
| US-20090318542-A1 | OPHTHAMOLOGICAL DRUGS | QDPR, PTGIR, PDE6C | CA1 1965/4885CA2 136/4885CA7 275/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.