SCHEMBL4410331

SCHEMBL4410331

CCCS(=O)(=O)Nc1cc(C(C)(C)C)cc(NC(=O)C(=O)c2ccc(OC[C@@H](O)CO)c3ccccc23)c1OC

nearest known ligand 0.68

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SCARB1 Q8WTV0 15/20 0.68
MAPK14 Q16539 5/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4410336 1.00 SCARB1 (0.68) SCARB1MAPK14
SCHEMBL1600950 0.89 SCARB1 (0.73) SCARB1MAPK14
SCHEMBL4949172 0.86 SCARB1 (0.72) SCARB1MAPK14
SCHEMBL12669830 0.84 SCARB1 (0.67) SCARB1MAPK14
SCHEMBL1600149 0.81 SCARB1 (1.00) SCARB1MAPK14
SCHEMBL5820136 0.81 SCARB1 (0.77) SCARB1MAPK14
SCHEMBL1600035 0.78 SCARB1 (0.74) SCARB1MAPK14
SCHEMBL1600480 0.77 SCARB1 (0.79) SCARB1MAPK14
SCHEMBL1600378 0.77 SCARB1 (0.78) SCARB1MAPK14
SCHEMBL12669833 0.77 SCARB1 (0.76) SCARB1MAPK14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2006091862-A2 CYTOKINE INHIBITORS AND THEIR USE IN THERAPY KEMIA, INC. (US) 2006-08-31 WO claimed
EP-2035005-A2 THERAPY USING CYTOKINE INHIBITORS Kemia, INC. (US) 2009-03-18 EP disclosed
WO-2007146712-A2 THERAPY USING CYTOKINE INHIBITORS KEMIA, INC. (US) 2007-12-21 WO disclosed
WO-2006091862-A2 CYTOKINE INHIBITORS AND THEIR USE IN THERAPY KEMIA, INC. (US) 2006-08-31 WO disclosed