Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 3/20 | 0.41 |
| ▸ | KCNN4 | O15554 | 14/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL985486 | 0.93 | MAP4K4 (0.49) | MAP4K4KCNN4TGFBR1ACVR1ACHE | |
| SCHEMBL986129 | 0.88 | ALDH1A1 (0.46) | MAP4K4KCNN4CHEK2TGFBR1ACVR1 | |
| SCHEMBL984954 | 0.86 | KCNN4 (0.42) | KCNN4ACHE | |
| SCHEMBL985174 | 0.86 | KCNN4 (0.45) | MAP4K4KCNN4ACHE | |
| SCHEMBL986729 | 0.85 | KCNN4 (0.42) | MAP4K4KCNN4CHEK2 | |
| SCHEMBL27918495 | 0.85 | KCNN4 (0.41) | KCNN4ACHE | |
| SCHEMBL988087 | 0.85 | KCNN4 (0.41) | KCNN4ACHE | |
| SCHEMBL982622 | 0.85 | USP7 (0.48) | MAP4K4KCNN4TGFBR1 | |
| SCHEMBL984938 | 0.85 | KCNN4 (0.46) | MAP4K4KCNN4ACHE | |
| SCHEMBL27900679 | 0.85 | KCNN4 (0.39) | KCNN4ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004625-B1 | C-MET PROTEIN KINASE INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | VERTEX PHARMA (US) | 2009-12-30 | — | — | EP | claimed |