⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7901265 | 1.00 | — | — | |
| SCHEMBL93684 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL29472117 | 0.98 | — | — | |
| SCHEMBL9871440 | 0.88 | MAPT (0.30) | — | |
| SCHEMBL22702323 | 0.86 | — | — | |
| SCHEMBL10598894 | 0.86 | — | — | |
| SCHEMBL29471433 | 0.84 | — | — | |
| SCHEMBL19345925 | 0.84 | BRD4 (0.38) | — | |
| SCHEMBL31682403 | 0.76 | — | — | |
| SCHEMBL12801363 | 0.76 | MAPT (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3190111-B1 | PYRAZOLO[3,4-C]PYRIDINE DERIVATIVES | CSPC ZHONGQI PHARMACEUTICAL TECH SHIJIAZHUANG CO LTD (CN) | 2020-05-06 | — | — | EP | disclosed |
| US-20170291896-A1 | PYRAZOLO[3,4-C]PYRIDINE DERIVATIVES | CSPC ZHONGQI PHARMACEUTICAL TECHNOLOGY (SHIJIAZHUANG) CO., LTD. (CN) | 2017-10-12 | — | — | US | disclosed |
| EP-3190111-A1 | PYRAZOLO[3,4-C]PYRIDINE DERIVATIVES | CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. (CN) | 2017-07-12 | — | — | EP | disclosed |
| WO-2016034137-A1 | PYRAZOLO[3,4-C]PYRIDINE DERIVATIVES | 石药集团中奇制药技术（石家庄）有限公司 | 2016-03-10 | — | — | WO | disclosed |
| US-8987268-B2 | Pyrrolopyridazine JAK3 inhibitors and their use for the treatment of inflammatory and autoimmune diseases | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-03-24 | — | — | US | disclosed |
| US-20140011800-A1 | PYRROLOPYRIDAZINE JAK3 INHIBITORS AND THEIR USE FOR THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES | BRISTOL-MYERS SQUIBB COMPANY | 2014-01-09 | — | — | US | disclosed |
| US-8383625-B2 | Pyrrolidinium derivatives as M3 muscarnic receptor antagonists | NOVARTIS AG (CH) | 2013-02-26 | — | — | US | disclosed |
| CN-101087777-B | Pyrrolidinium derivatives as M3 muscarinic receptors | NOVARTIS AG | 2010-12-08 | — | — | CN | disclosed |
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |
| US-20090311178-A1 | PYRROLINIDIUM DERIVATIVES AS M3 MUSCARINIC RECEPTORS | GE HEALTHCARE LIMITED (GB) | 2009-12-17 | — | — | US | disclosed |
| CN-101087777-A | Pyrrolidinium derivatives as M3 muscarinic receptors | NOVARTIS AG (CH) | 2007-12-12 | — | — | CN | disclosed |