⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7901265 | 1.00 | — | — | |
| SCHEMBL4411546 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL29472117 | 0.98 | — | — | |
| SCHEMBL9871440 | 0.88 | MAPT (0.30) | — | |
| SCHEMBL22702323 | 0.86 | — | — | |
| SCHEMBL10598894 | 0.86 | — | — | |
| SCHEMBL29471433 | 0.84 | — | — | |
| SCHEMBL19345925 | 0.84 | BRD4 (0.38) | — | |
| SCHEMBL31682403 | 0.76 | — | — | |
| SCHEMBL12801363 | 0.76 | MAPT (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 291 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4467199-A2 | SMALL MOLECULE INHIBITORS OF NF-KB INDUCING KINASE | JANSSEN Pharmaceutica NV (BE) | 2024-11-27 | — | — | EP | claimed |
| US-20240199605-A1 | SMALL MOLECULAR INHIBITORS OF NF-kB INDUCING KINASE | JANSSEN PHARMACEUTICA NV (BE) | 2024-06-20 | — | — | US | claimed |
| CN-114222737-A | Small molecule inhibitor of NF-kB induced kinase | 詹森药业有限公司 | 2022-03-22 | — | — | CN | claimed |
| CN-113797180-A | Percutaneous absorption preparation containing donepezil as active ingredient | Icure药品株式会社 | 2021-12-17 | — | — | CN | claimed |
| US-10888533-B2 | Transdermal composition containing donepezil as active ingredient | ICURE PHARMACEUTICAL INC. (KR) | 2021-01-12 | — | — | US | claimed |
| US-20190091168-A1 | FORMULATION FOR ENHANCED TRANSDERMAL ABSORPTION OF DRUG | UNIST(ULSAN NATIONAL INSTITUTE OF SCIENCE AND TECHNOLOGY) (KR) | 2019-03-28 | — | — | US | claimed |
| EP-3235494-A1 | TRANSDERMAL PREPARATION CONTAINING DONEPEZIL AS ACTIVE INGREDIENT | Icure Pharmaceutical Inc. (KR) | 2017-10-25 | — | — | EP | claimed |
| US-20170290780-A1 | TRANSDERMAL COMPOSITION CONTAINING DONEPEZIL AS ACTIVE INGREDIENT | ICURE PHARMACEUTICAL INC. (KR) | 2017-10-12 | — | — | US | claimed |
| CN-107106510-A | Percutaneous absorption preparation containing donepezil as active ingredient | Icure药品株式会社 | 2017-08-29 | — | — | CN | claimed |
| US-9090605-B2 | Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use | VITAE PHARMACEUTICALS, INC. (US) | 2015-07-28 | — | — | US | claimed |
| US-20070269379-A1 | Penetration Enhancer Combinations for Transdermal Delivery | REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE | 2007-11-22 | — | — | US | claimed |
| US-7137975-B2 | Method for increasing the battery life of an alternating current iontophoresis device using a barrier-modifying agent | ACIONT, INC. (US) | 2006-11-21 | — | — | US | claimed |
| WO-2005009510-A2 | PENETRATION ENHANCER COMBINATIONS FOR TRANSDERMAL DELIVERY | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2005-02-03 | — | — | WO | claimed |
| US-6673841-B2 | TREATMENT OF ERECTILE DYSFUNCTION | WHAN IN PHARM. CO., LTD. (KR) | 2004-01-06 | — | — | US | claimed |
| US-20030125382-A1 | Alprostadil alkyl ester-containing composition for external application | WHAN IN PHARM. CO., LTD. | 2003-07-03 | — | — | US | claimed |
| US-6500440-B1 | PREPARATION COMPRISING ALPROSTADIL IN OILY VEHICLE WITH SKIN PERMEATION ENHANCER, ANTI-IRRITANT AGENT AND THICKENER | WHAN IN PHARM CO., LTD. (KR) | 2002-12-31 | — | — | US | claimed |
| US-20020161323-A1 | Method for increasing the battery life of an alternating current iontophoresis device using a barrier-modifying agent | ACIONT INC. | 2002-10-31 | — | — | US | claimed |
| WO-2001097777-A1 | TOPICAL PREPARATION OF ALPROSTADIL FOR THE TREATMENT OF ERECTILE DYSFUNCTION | WHAN IN PHARM. CO. LTD. (KR) | 2001-12-27 | — | — | WO | claimed |
| US-5032402-A | 3-hydroxy-N-methylpyrrolidone and use as transdermal enhancer | THE UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 1991-07-16 | — | — | US | claimed |
| US-4973708-A | TRANSDERMAL ENHANCER FOR PENETRATION OF DRUGS THROUGH THE SKIN | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 1990-11-27 | — | — | US | claimed |