Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | MMP1 | P03956 | 2/20 | 0.36 |
| ▸ | MMP2 | P08253 | 2/20 | 0.36 |
| ▸ | MMP9 | P14780 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.36 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.36 |
| ▸ | MEF2D | Q14814 | 2/20 | 0.36 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4411726 | 1.00 | POLB (0.45) | POLBKMT2AMEN1HPGDALDH1A1 | |
| SCHEMBL4183196 | 0.83 | NR1H4 (0.38) | POLBKMT2AMEN1HPGDALDH1A1 | |
| SCHEMBL4183191 | 0.83 | NR1H4 (0.38) | POLBKMT2AMEN1HPGDALDH1A1 | |
| SCHEMBL4166783 | 0.82 | RAF1 (0.40) | POLBKMT2AMEN1HPGDALDH1A1 | |
| SCHEMBL4166787 | 0.82 | RAF1 (0.40) | POLBKMT2AMEN1HPGDALDH1A1 | |
| SCHEMBL4422604 | 0.78 | KMT2A (0.43) | POLBKMT2AMEN1HPGDALDH1A1 | |
| SCHEMBL4422602 | 0.78 | KMT2A (0.43) | POLBKMT2AMEN1HPGDALDH1A1 | |
| SCHEMBL4659414 | 0.75 | CTBP2 (0.54) | POLBKMT2AMEN1HPGDALDH1A1 | |
| SCHEMBL4185989 | 0.72 | RAF1 (0.44) | POLBKMT2AMEN1HPGDALDH1A1 | |
| SCHEMBL4185994 | 0.72 | RAF1 (0.44) | POLBKMT2AMEN1HPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2076124-A2 | STYRENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2009-07-08 | — | — | EP | disclosed |
| WO-2008131368-A2 | STYRENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA INC. (US) | 2008-10-30 | — | — | WO | disclosed |