Pizotyline

Pizotyline

SCHEMBL44122

CN1CCC(=C2c3ccccc3CCc3sccc32)CC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DRD1 P21728 7/20 1.00
DRD3 P35462 7/20 1.00
CHRM2 P08172 6/20 1.00
CHRM1 P11229 6/20 1.00
DRD2 P14416 6/20 1.00
ADRA1A P35348 5/20 1.00
KCNH2 Q12809 5/20 1.00
ADRA2A P08913 5/20 1.00
HTR2A P28223 5/20 1.00
HTR2C P28335 5/20 1.00
HRH1 P35367 5/20 1.00
HTR2B P41595 4/20 1.00
ADRA2B P18089 4/20 1.00
LMNA P02545 4/20 1.00
HTR1A P08908 4/20 1.00
OPRK1 P41145 3/20 1.00
HTR3A P46098 3/20 1.00
ADRA2C P18825 3/20 1.00
ADRA1D P25100 3/20 1.00
SLC6A2 P23975 3/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pizotyline SCHEMBL29366884 1.00 DRD1 (1.00) DRD1DRD3CHRM2CHRM1DRD2
Pizotyline SCHEMBL8771138 1.00 DRD1 (1.00) DRD1DRD3CHRM2CHRM1DRD2
Pizotyline SCHEMBL11436430 0.99 DRD1 (0.97) DRD1DRD3CHRM2CHRM1DRD2
Pizotyline SCHEMBL1000901 0.89 MAPK1 (1.00) DRD1DRD3CHRM2CHRM1DRD2
Pizotyline SCHEMBL1000902 0.89 MAPK1 (1.00) DRD1DRD3CHRM2CHRM1DRD2
SCHEMBL7817056 0.86 SETD7 (1.00) DRD1DRD3CHRM2CHRM1DRD2
Pizotyline SCHEMBL365598 0.83 CYP2D6 (1.00) DRD1DRD3CHRM2CHRM1DRD2
SCHEMBL3044995 0.82 DRD3 (0.70) DRD1DRD3CHRM2CHRM1DRD2
SCHEMBL11601745 0.82 MAPK1 (0.69) DRD1DRD3CHRM2CHRM1DRD2
SCHEMBL21859441 0.82 CHRM2 (0.69) DRD1DRD3CHRM2CHRM1DRD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 5808 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4725483-A1 COMBINATION COMPRISING AT LEAST ONE 5-HT2A RECEPTOR ANTAGONIST AND AT LEAST ONE 5-HT3 RECEPTOR ANTAGONIST AND ITS MEDICAL USE Université de Bordeaux (FR) 2026-04-15 EP claimed
US-20260083759-A1 Combinations Comprising Psychedelics for the Treatment of Schizophrenia and Other Neuropsychiatric and Neurologic Disorders HADASIT MED RES SERVICE (IL) 2026-03-26 US claimed
US-20250295611-A1 METHODS OF TREATING 5HT2A RECEPTOR-MEDIATED CONDITIONS TESSELLATE THERAPEUTICS INC (US) 2025-09-25 US claimed
EP-4154879-B1 PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING NICOTINE WITHDRAWAL SYMPTOMS KOREA INST SCI & TECH (KR) 2025-09-10 EP claimed
US-20250263474-A1 TREATING REFRACTORY MIGRAINE TEVA PHARMACEUTICALS INTERNATIONAL GMBH (CH) 2025-08-21 US claimed
EP-4583858-A1 COMBINATIONS COMPRISING PSYCHEDELICS FOR THE TREATMENT OF SCHIZOPHRENIA AND OTHER NEUROPSYCHIATRIC AND NEUROLOGIC DISORDERS Hadasit Medical Research Services&Development Ltd. (IL) 2025-07-16 EP claimed
US-20250213647-A1 CHEMOKINE RECEPTORS AND ALPHA1 ADRENERGIC RECEPTORS/VASOPRESSIN RECEPTORS 1A HETEROMERS AS DRUG TARGETS FOR DISEASE UNIVERSITY OF SOUTH FLORIDA 2025-07-03 US claimed
WO-2025111482-A1 COMPLEXING AGENT SALT FORMULATIONS OF PHARMACEUTICAL COMPOUNDS AT LOW STOICHIOMETRIC RATIOS BEXSON BIOMEDICAL, INC. (US) 2025-05-30 WO claimed
US-20250170143-A1 METHODS OF TREATING OCULAR FIBROTIC PATHOLOGIES MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH 2025-05-29 US claimed
CN-120044159-A Polygonatum sibiricum medicinal material species identification method based on polygonatum sibiricum characteristic compound and application 河北北方学院 2025-05-27 CN claimed
EP-1011656-A2 A METHOD FOR TREATING TENSION-TYPE HEADACHE Head Explorer ApS (DK) 2000-06-28 EP claimed
JP-2000500446-A 2000-01-18 JP claimed
US-5942503-A Use of Epinastine for the treatment of pain BOEHRINGER INDELHEIM KG (DE) 1999-08-24 US claimed
CN-1202111-A Use of epinastine in the treatment of pain BOEHRINGER INGELHEIM KG (DE) 1998-12-16 CN claimed
EP-0861081-A1 USE OF EPINASTINE IN THE TREATMENT OF PAIN BOEHRINGER INGELHEIM KG (DE) 1998-09-02 EP claimed
WO-1998019674-A2 A METHOD FOR TREATING TENSION-TYPE HEADACHE HEAD EXPLORER APS (DK) 1998-05-14 WO claimed
WO-1997041878-A1 TREATMENT OF MOOD DISORDERS WITH A GROWTH HORMONE SECRETAGOGUE MERCK & CO., INC. (US) 1997-11-13 WO claimed
WO-1997017971-A1 USE OF EPINASTINE IN THE TREATMENT OF PAIN BOEHRINGER INGELHEIM KG (DE) 1997-05-22 WO claimed
EP-0487674-B1 INJECTABLE SLOW-RELEASE GALENICAL APLICACIONES FARMACEUTICAS (MX) 1995-01-25 EP claimed
US-4444778-A ANTISEROTONINE AGENTS COUGHLIN SHAUN R 1984-04-24 US claimed