Pizotyline

Pizotyline

SCHEMBL8771138

CN1CCC(=C2c3ccccc3CCc3sccc32)CC1.CN1CCC(=C2c3ccccc3CCc3sccc32)CC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DRD1 P21728 7/20 1.00
DRD3 P35462 7/20 1.00
CHRM2 P08172 6/20 1.00
CHRM1 P11229 6/20 1.00
DRD2 P14416 6/20 1.00
ADRA1A P35348 5/20 1.00
KCNH2 Q12809 5/20 1.00
ADRA2A P08913 5/20 1.00
HTR2A P28223 5/20 1.00
HTR2C P28335 5/20 1.00
HRH1 P35367 5/20 1.00
HTR2B P41595 4/20 1.00
ADRA2B P18089 4/20 1.00
LMNA P02545 4/20 1.00
HTR1A P08908 4/20 1.00
OPRK1 P41145 3/20 1.00
HTR3A P46098 3/20 1.00
ADRA2C P18825 3/20 1.00
ADRA1D P25100 3/20 1.00
SLC6A2 P23975 3/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pizotyline SCHEMBL29366884 1.00 DRD1 (1.00) DRD1DRD3CHRM2CHRM1DRD2
Pizotyline SCHEMBL44122 1.00 DRD1 (1.00) DRD1DRD3CHRM2CHRM1DRD2
Pizotyline SCHEMBL11436430 0.99 DRD1 (0.97) DRD1DRD3CHRM2CHRM1DRD2
Pizotyline SCHEMBL1000901 0.89 MAPK1 (1.00) DRD1DRD3CHRM2CHRM1DRD2
Pizotyline SCHEMBL1000902 0.89 MAPK1 (1.00) DRD1DRD3CHRM2CHRM1DRD2
SCHEMBL7817056 0.86 SETD7 (1.00) DRD1DRD3CHRM2CHRM1DRD2
Pizotyline SCHEMBL365598 0.83 CYP2D6 (1.00) DRD1DRD3CHRM2CHRM1DRD2
SCHEMBL3044995 0.82 DRD3 (0.70) DRD1DRD3CHRM2CHRM1DRD2
SCHEMBL11601745 0.82 MAPK1 (0.69) DRD1DRD3CHRM2CHRM1DRD2
SCHEMBL21859441 0.82 CHRM2 (0.69) DRD1DRD3CHRM2CHRM1DRD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0796254-A1 METHOD FOR SELECTIVELY PREPARING 2,5-FURANDICARBOXALDEHYDE FROM 5-HYDROXYMETHYL FURAN 2-CARBOXALDEHYDE AGRICHIMIE (FR) 1997-09-24 EP disclosed
WO-1996017836-A1 METHOD FOR SELECTIVELY PREPARING 2,5-FURANDICARBOXALDEHYDE FROM 5-HYDROXYMETHYL FURAN 2-CARBOXALDEHYDE AGRICHIMIE (FR) 1996-06-13 WO disclosed