Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 2/20 | 0.72 |
| ▸ | GABRA1 | P14867 | 6/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 6/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 6/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 6/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 6/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 6/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.42 |
| ▸ | CCKBR | P32239 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | GABRP | O00591 | 1/20 | 0.40 |
| ▸ | GABRD | O14764 | 1/20 | 0.40 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.40 |
| ▸ | ALB | P02768 | 1/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | GABRE | P78334 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4423105 | 0.93 | PDE2A (0.63) | PDE2AGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL4709995 | 0.93 | PDE2A (0.72) | PDE2AGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL4412620 | 0.89 | PDE2A (0.60) | PDE2AFYNPDE4DATRHDAC1 | |
| SCHEMBL4424399 | 0.89 | PDE2A (0.60) | PDE2AFYNPDE4DATRERN1 | |
| SCHEMBL4708377 | 0.88 | PDE2A (0.66) | PDE2AGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL4411561 | 0.87 | PDE2A (0.58) | PDE2AFYNLMNA | |
| SCHEMBL4412511 | 0.87 | GABRA1 (0.54) | PDE2AGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL4602359 | 0.87 | PDE2A (0.58) | PDE2AFYNPDE4DATRHDAC1 | |
| SCHEMBL4709022 | 0.87 | PDE2A (0.66) | PDE2AGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL4414019 | 0.86 | PDE2A (0.57) | PDE2AOPRK1KCNH2PDE4DLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090215752-A1 | Compounds, preparation and therapeutic use thereof | BAY CITY CAPITAL LLC | 2009-08-27 | — | — | US | claimed |
| EP-1910315-A2 | BENZODIAZEPINE DERIVATIVES, THEIR PREPARATION AND THE THERAPEUTIC USE THEREOF | NEURO3D (FR) | 2008-04-16 | — | — | EP | claimed |
| WO-2007026254-A2 | BENZODIAZEPINE DERIVATIVES , THEIR PREPARATION AND THE THERAPEUTIC USE THEREOF | NEURO3D (FR) | 2007-03-08 | — | — | WO | claimed |
| EP-1749824-A1 | Benzodiazepine derivatives, their preparation and the therapeutic use thereof | NEURO3D (FR) | 2007-02-07 | — | — | EP | claimed |
| US-20090215752-A1 | Compounds, preparation and therapeutic use thereof | BAY CITY CAPITAL LLC | 2009-08-27 | — | — | US | disclosed |
| EP-1749824-A1 | Benzodiazepine derivatives, their preparation and the therapeutic use thereof | NEURO3D (FR) | 2007-02-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215752-A1 | Compounds, preparation and therapeutic use thereof | PDE12, PDE4B, PDE2A | PDE2A 3/4885GABRA1 60/4885GABRG2 72/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.