Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2A known ✓ | Q12879 | 1/20 | 0.38 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.43 |
| ▸ | GRIK1 | P39086 | 5/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.41 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 3/20 | 0.40 |
| ▸ | NOS3 | P29474 | 2/20 | 0.40 |
| ▸ | NOS1 | P29475 | 2/20 | 0.40 |
| ▸ | SLC1A2 | P43004 | 6/20 | 0.39 |
| ▸ | SLC1A3 | P43003 | 5/20 | 0.39 |
| ▸ | SLC1A1 | P43005 | 5/20 | 0.39 |
| ▸ | GRIK2 | Q13002 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | GRM8 | O00222 | 1/20 | 0.38 |
| ▸ | GRM6 | O15303 | 1/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.38 |
| ▸ | GSR | P00390 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL4412730 | 1.00 | SLC7A5 (0.43) | SLC7A5GRIK1PTGS1SLC7A11NOS2 | |
| SCHEMBL890414 | 0.98 | SLC7A5 (0.44) | SLC7A5GRIK1PTGS1SLC7A11NOS2 | |
| SCHEMBL890415 | 0.98 | SLC7A5 (0.44) | SLC7A5GRIK1PTGS1SLC7A11NOS2 | |
| Hydrochloric Acid SCHEMBL4408945 | 0.95 | SLC7A5 (0.43) | SLC7A5GRIK1PTGS1SLC7A11NOS2 | |
| Hydrochloric Acid SCHEMBL3870800 | 0.95 | SLC7A5 (0.43) | SLC7A5GRIK1PTGS1SLC7A11NOS2 | |
| SCHEMBL19918392 | 0.84 | SLC7A5 (0.44) | SLC7A5GRIK1PTGS1SLC7A11NOS2 | |
| SCHEMBL936382 | 0.84 | SLC7A5 (0.44) | SLC7A5GRIK1PTGS1SLC7A11NOS2 | |
| SCHEMBL1146973 | 0.84 | SLC7A5 (0.44) | SLC7A5GRIK1PTGS1SLC7A11NOS2 | |
| Hydrochloric Acid SCHEMBL18762600 | 0.82 | SLC7A5 (0.43) | SLC7A5GRIK1PTGS1SLC7A11NOS2 | |
| SCHEMBL18774960 | 0.80 | SLC7A5 (0.41) | SLC7A5GRIK1PTGS1SLC7A11NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140073662-A1 | Spirocyclic nitriles as protease inhibitors | SANOFI (FR) | 2014-03-13 | — | — | US | disclosed |
| US-8609681-B2 | Spirocyclic nitriles as protease inhibitors | SANOFI (FR) | 2013-12-17 | — | — | US | disclosed |
| US-20090275523-A1 | Spirocyclic nitriles as protease inhibitors | SANOFI-AVENTIS (FR) | 2009-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275523-A1 | Spirocyclic nitriles as protease inhibitors | CTRL, SERPINB1, PREP | GRIN2A 3014/4885SLC7A5 2914/4885GRIK1 2331/4885 |
| US-20140073662-A1 | Spirocyclic nitriles as protease inhibitors | CTRL, SERPINB1, PREP | GRIN2A 3014/4885SLC7A5 2914/4885GRIK1 2331/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.