Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 2/20 | 0.54 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.53 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.50 |
| ▸ | HTR2A | P28223 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.49 |
| ▸ | HRH1 | P35367 | 2/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.49 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.48 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4551826 | 0.99 | MCHR1 (0.53) | CHRM2DPP7MCHR1HDAC1CHRM1 | |
| SCHEMBL4419042 | 0.91 | DPP7 (0.64) | CHRM2DPP7MCHR1CHRM1HTR2A | |
| SCHEMBL5867373 | 0.90 | DPP7 (0.62) | DPP7MCHR1CHRM1HTR2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6341357 | 0.90 | CHRM2 (0.60) | CHRM2DPP7SMN1; SMN2HRH3SLC6A2 | |
| SCHEMBL2444186 | 0.89 | CHRM2 (0.62) | CHRM2DPP7SMN1; SMN2 | |
| SCHEMBL4418818 | 0.89 | CHRM2 (0.51) | CHRM2SMN1; SMN2HRH3SIGMAR1TMEM97 | |
| Hydrochloric Acid SCHEMBL6345757 | 0.88 | CHRM2 (0.63) | CHRM2DPP7SMN1; SMN2HRH3SLC6A2 | |
| SCHEMBL3179432 | 0.87 | DPP7 (0.66) | DPP7HDAC1SCN5A | |
| SCHEMBL4425761 | 0.87 | CYP2C19 (0.65) | CHRM2SMN1; SMN2HRH3 | |
| SCHEMBL18769662 | 0.86 | DPP7 (0.70) | CHRM2DPP7SMN1; SMN2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1479671-B1 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2009-05-27 | — | — | EP | disclosed |
| US-7115616-B2 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2006-10-03 | — | — | US | disclosed |
| US-6953803-B1 | 1-[(N-(2-(diethylamino)ethyl)-N-(4-(4-trifluoromethylphenyl)benzyl)aminocarbonylmethyl)]-2-(4-fluorobenzyl)thio-5-(1-methyl-4-pyrazolylmethyl)pyrimidin-4-one; enzyme inhibitors of lipoprotein associated phospholipase A2 (Lp-PLA2); atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 2005-10-11 | — | — | US | disclosed |