Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.64 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.52 |
| ▸ | HTR2A | P28223 | 2/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5867373 | 0.98 | DPP7 (0.62) | DPP7MCHR1GAASMN1; SMN2CHRM1 | |
| SCHEMBL18769662 | 0.95 | DPP7 (0.70) | DPP7GAASMN1; SMN2SIGMAR1KDM4E | |
| SCHEMBL18769723 | 0.94 | DPP7 (0.68) | DPP7MCHR1GAASMN1; SMN2SIGMAR1 | |
| Hydrochloric Acid SCHEMBL5760498 | 0.94 | DPP7 (0.68) | DPP7GAASMN1; SMN2SIGMAR1KDM4E | |
| Hydrochloric Acid SCHEMBL5758747 | 0.92 | DPP7 (0.66) | DPP7GAASMN1; SMN2SIGMAR1KDM4E | |
| SCHEMBL4412835 | 0.91 | CHRM2 (0.54) | DPP7MCHR1SMN1; SMN2CHRM1HTR2A | |
| SCHEMBL4551826 | 0.90 | MCHR1 (0.53) | DPP7MCHR1CHRM1HTR2ASIGMAR1 | |
| SCHEMBL12332378 | 0.89 | DPP7 (0.59) | DPP7GAASMN1; SMN2SIGMAR1KDM4E | |
| SCHEMBL4424517 | 0.88 | CNR1 (0.52) | DPP7GAASMN1; SMN2SIGMAR1ALDH1A1 | |
| SCHEMBL4423135 | 0.87 | POLB (0.58) | SMN1; SMN2ALDH1A1CNR1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1479671-B1 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2009-05-27 | — | — | EP | disclosed |
| US-7115616-B2 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2006-10-03 | — | — | US | disclosed |
| US-6953803-B1 | 1-[(N-(2-(diethylamino)ethyl)-N-(4-(4-trifluoromethylphenyl)benzyl)aminocarbonylmethyl)]-2-(4-fluorobenzyl)thio-5-(1-methyl-4-pyrazolylmethyl)pyrimidin-4-one; enzyme inhibitors of lipoprotein associated phospholipase A2 (Lp-PLA2); atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 2005-10-11 | — | — | US | disclosed |
| EP-1175408-A1 | PYRIMIDINONE COMPOUNDS | SMITHKLINE BEECHAM PLC (GB) | 2002-01-30 | — | — | EP | disclosed |
| WO-2000066567-A1 | PYRIMIDINONE COMPOUNDS | SMITHKLINE BEECHAM PLC (GB) | 2000-11-09 | — | — | WO | disclosed |