Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MGAM | O43451 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SI | P14410 | 1/20 | 0.38 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TLR4 | O00206 | 1/20 | 0.36 |
| ▸ | TLR2 | O60603 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4168767 | 0.84 | RAB9A (0.55) | RAB9AKMT2ATDP1L3MBTL1MEN1 | |
| SCHEMBL4168775 | 0.84 | RAB9A (0.55) | RAB9AKMT2ATDP1L3MBTL1MEN1 | |
| SCHEMBL10291506 | 0.73 | RAB9A (0.57) | RAB9AKMT2ATDP1L3MBTL1MEN1 | |
| SCHEMBL4569056 | 0.73 | RAB9A (0.57) | RAB9AKMT2ATDP1L3MBTL1MEN1 | |
| SCHEMBL2209008 | 0.73 | RAB9A (0.57) | RAB9AKMT2ATDP1L3MBTL1MEN1 | |
| SCHEMBL2208841 | 0.73 | RAB9A (0.57) | RAB9AKMT2ATDP1L3MBTL1MEN1 | |
| SCHEMBL2207764 | 0.71 | RAB9A (0.61) | RAB9AKMT2ATDP1L3MBTL1MEN1 | |
| SCHEMBL2208993 | 0.70 | RAB9A (0.60) | RAB9AKMT2ATDP1L3MBTL1MEN1 | |
| SCHEMBL2207552 | 0.70 | RAB9A (0.60) | RAB9AKMT2ATDP1L3MBTL1MEN1 | |
| SCHEMBL4569044 | 0.70 | RAB9A (0.60) | RAB9AKMT2ATDP1L3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2076124-A2 | STYRENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2009-07-08 | — | — | EP | disclosed |
| WO-2008131368-A2 | STYRENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA INC. (US) | 2008-10-30 | — | — | WO | disclosed |