Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 19/20 | 0.47 |
| ▸ | KDR | P35968 | 3/20 | 0.42 |
| ▸ | FLT3 | P36888 | 2/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | MST1R | Q04912 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20525860 | 0.87 | MET (0.46) | METKDRFLT3KIT | |
| SCHEMBL2328224 | 0.87 | MET (0.43) | METKDRFLT3 | |
| SCHEMBL407663 | 0.86 | MET (0.46) | METKDRMST1R | |
| SCHEMBL2330038 | 0.84 | MET (0.45) | METKDR | |
| SCHEMBL3836125 | 0.83 | MET (0.50) | METFLT3 | |
| SCHEMBL3835125 | 0.83 | MET (0.49) | METKDRFLT3KITMST1R | |
| SCHEMBL3854982 | 0.83 | MET (0.49) | METKDRFLT3KITMST1R | |
| SCHEMBL4413202 | 0.83 | MET (0.52) | METKDRFLT3KITMST1R | |
| SCHEMBL3832694 | 0.82 | MET (0.53) | METKDRFLT3 | |
| SCHEMBL3835182 | 0.82 | MET (0.51) | METKDRFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7579473-B2 | N-(4-{[7-{[3-(diethylamino)propyl] oxy}-6-(methyloxy) quinazolin-4-yl]oxy}-3- fluorophenyl)-N'-(4- fluorophenyl) cyclopropane-1,1-dicarboxamide; for modulating protein kinase enzymatic activity for modulating cell activities such as proliferation, differentiation, programmed cell death | EXELIXIS, INC. (US) | 2009-08-25 | — | — | US | disclosed |