Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 3/20 | 0.61 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.61 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.61 |
| ▸ | RET | P07949 | 1/20 | 0.61 |
| ▸ | KIT | P10721 | 1/20 | 0.61 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.61 |
| ▸ | MET | P08581 | 6/20 | 0.51 |
| ▸ | AXL | P30530 | 6/20 | 0.50 |
| ▸ | MERTK | Q12866 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 8/20 | 0.49 |
| ▸ | FLT3 | P36888 | 2/20 | 0.49 |
| ▸ | FLT4 | P35916 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22104163 | 0.86 | PDGFRA (0.72) | CSF1RPDGFRBPDGFRARETKIT | |
| SCHEMBL31324684 | 0.86 | PDGFRA (0.72) | CSF1RPDGFRBPDGFRARETKIT | |
| SCHEMBL29693548 | 0.84 | PDGFRB (0.62) | CSF1RPDGFRBPDGFRARETKIT | |
| SCHEMBL31324666 | 0.84 | PDGFRB (0.62) | CSF1RPDGFRBPDGFRARETKIT | |
| SCHEMBL372681 | 0.84 | PDGFRB (0.62) | CSF1RPDGFRBPDGFRARETKIT | |
| SCHEMBL371958 | 0.83 | PDGFRA (0.61) | CSF1RPDGFRBPDGFRAKITMET | |
| SCHEMBL378510 | 0.82 | KDR (0.59) | CSF1RPDGFRBPDGFRARETKIT | |
| SCHEMBL29693652 | 0.82 | KDR (0.59) | CSF1RPDGFRBPDGFRARETKIT | |
| SCHEMBL371670 | 0.81 | MET (0.60) | CSF1RPDGFRBPDGFRARETKIT | |
| SCHEMBL371579 | 0.81 | KDR (0.55) | CSF1RPDGFRBPDGFRAKITMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7579473-B2 | N-(4-{[7-{[3-(diethylamino)propyl] oxy}-6-(methyloxy) quinazolin-4-yl]oxy}-3- fluorophenyl)-N'-(4- fluorophenyl) cyclopropane-1,1-dicarboxamide; for modulating protein kinase enzymatic activity for modulating cell activities such as proliferation, differentiation, programmed cell death | EXELIXIS, INC. (US) | 2009-08-25 | — | — | US | disclosed |