Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.65 |
| ▸ | GSK3A | P49840 | 8/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 4/20 | 0.43 |
| ▸ | SYK | P43405 | 4/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4551684 | 0.86 | MAPK14 (0.59) | MAPK14MAPTBRAF | |
| SCHEMBL1598861 | 0.83 | MAPK14 (0.67) | MAPK14GSK3ASRCSYKBRAF | |
| SCHEMBL1600434 | 0.82 | MAPK14 (0.65) | MAPK14BRAF | |
| SCHEMBL1599788 | 0.81 | MAPK14 (0.78) | MAPK14GSK3ABRAF | |
| SCHEMBL1600022 | 0.81 | MAPK14 (0.57) | MAPK14GSK3AMAPTSRCSYK | |
| SCHEMBL1600895 | 0.79 | MAPK14 (0.65) | MAPK14 | |
| SCHEMBL1600200 | 0.79 | MAPK14 (0.82) | MAPK14GSK3A | |
| SCHEMBL1600212 | 0.79 | MAPK14 (0.67) | MAPK14GSK3ASRCSYKBRAF | |
| SCHEMBL1600485 | 0.79 | MAPK14 (1.00) | MAPK14SRCBRAFMAPK12 | |
| SCHEMBL6305466 | 0.79 | MAPK14 (0.62) | MAPK14GSK3ASRCSYKMAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006091862-A2 | CYTOKINE INHIBITORS AND THEIR USE IN THERAPY | KEMIA, INC. (US) | 2006-08-31 | — | — | WO | claimed |
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2006091862-A2 | CYTOKINE INHIBITORS AND THEIR USE IN THERAPY | KEMIA, INC. (US) | 2006-08-31 | — | — | WO | disclosed |