Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 3/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.38 |
| ▸ | CDK2 | P24941 | 3/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4413461 | 0.86 | MAPK14 (0.65) | MAPK14MAPTBRAF | |
| SCHEMBL1599366 | 0.85 | MAPK14 (0.48) | MAPK14MAPK8CDC7BRAF | |
| SCHEMBL5805883 | 0.83 | MAPK14 (0.51) | MAPK14PKM | |
| SCHEMBL1599290 | 0.80 | MAPK14 (0.59) | MAPK14MAPK8BRAF | |
| SCHEMBL1600460 | 0.80 | MAPK14 (0.47) | MAPK14MAPK8CDC7ACHEAURKA | |
| SCHEMBL1599955 | 0.80 | MAPK14 (0.62) | MAPK14BRAF | |
| SCHEMBL4410744 | 0.79 | MAPK14 (0.55) | MAPK14MAPTALDH1A1PKM | |
| SCHEMBL1598985 | 0.78 | MAPK14 (0.61) | MAPK14MAPK8BRAF | |
| SCHEMBL1600014 | 0.78 | MAPK14 (0.64) | MAPK14 | |
| SCHEMBL1599065 | 0.78 | MAPK14 (0.61) | MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006091862-A2 | CYTOKINE INHIBITORS AND THEIR USE IN THERAPY | KEMIA, INC. (US) | 2006-08-31 | — | — | WO | claimed |
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007058990-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-05-24 | — | — | WO | disclosed |
| WO-2006091862-A2 | CYTOKINE INHIBITORS AND THEIR USE IN THERAPY | KEMIA, INC. (US) | 2006-08-31 | — | — | WO | disclosed |