Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 7/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 3/20 | 0.35 |
| ▸ | DRD5 | P21918 | 3/20 | 0.35 |
| ▸ | HKDC1 | Q2TB90 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4412186 | 0.89 | DRD1 (0.37) | SMN1; SMN2LMNAHPGDMEN1ALDH1A1 | |
| SCHEMBL3177139 | 0.84 | CDK1 (0.38) | CDK1SMN1; SMN2LMNAHPGDMEN1 | |
| SCHEMBL3177134 | 0.84 | CDK1 (0.38) | CDK1SMN1; SMN2LMNAHPGDMEN1 | |
| SCHEMBL4411114 | 0.81 | DRD1 (0.46) | LMNAKMT2ADRD1DRD5TSHR | |
| SCHEMBL4519246 | 0.80 | DRD1 (0.45) | CDK1SMN1; SMN2LMNAHPGDMEN1 | |
| SCHEMBL4427346 | 0.80 | DRD1 (0.53) | CDK1SMN1; SMN2LMNAMEN1MAPT | |
| SCHEMBL4521319 | 0.79 | DRD1 (0.46) | CDK1LMNAHPGDALDH1A1KMT2A | |
| SCHEMBL4506947 | 0.79 | DRD1 (0.55) | CDK1LMNADRD1DRD5NPC1 | |
| SCHEMBL4521605 | 0.78 | DRD1 (0.43) | CDK1LMNAKMT2ADRD1DRD5 | |
| SCHEMBL4559848 | 0.78 | DRD1 (0.47) | CDK1LMNAKMT2ADRD1DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009121036-A2 | SUBSTITUTED ARYL PYRIMIDINONE DERIVATIVES | NEUROGEN CORPORATION (US) | 2009-10-01 | — | — | WO | claimed |