SCHEMBL4413746

SCHEMBL4413746

CC(=O)Nc1cncc(NC(C)=O)n1

nearest known ligand 0.61

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.53
HSP90AA1 P07900 1/20 0.53
HSP90AB1 P08238 1/20 0.53
L3MBTL1 Q9Y468 1/20 0.50
PTK2 Q05397 1/20 0.47
LMNA P02545 1/20 0.46
BRAF P15056 3/20 0.45
ADORA3 P0DMS8 7/20 0.44
ADORA1 P30542 3/20 0.44
ADORA2B P29275 2/20 0.44
CYP1A2 P05177 2/20 0.44
GAA P10253 1/20 0.42
MAPK8 P45983 1/20 0.41
ADORA2A P29274 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1431348 0.87 KDM4E (0.47) KDM4EHSP90AA1HSP90AB1L3MBTL1PTK2
SCHEMBL19706555 0.86 KDM4E (0.46) KDM4EHSP90AA1HSP90AB1L3MBTL1PTK2
SCHEMBL21827821 0.86 KDM4E (0.46) KDM4EHSP90AA1HSP90AB1L3MBTL1PTK2
SCHEMBL21928148 0.86 KDM4E (0.46) KDM4EHSP90AA1HSP90AB1L3MBTL1PTK2
SCHEMBL6284192 0.86 PTK2 (0.49) KDM4EHSP90AA1HSP90AB1L3MBTL1PTK2
SCHEMBL14021067 0.82 KDM4E (0.44) KDM4EHSP90AA1HSP90AB1L3MBTL1PTK2
SCHEMBL14642747 0.82 KDM4E (0.44) KDM4EHSP90AA1HSP90AB1L3MBTL1PTK2
SCHEMBL13765787 0.82 KDM4E (0.44) KDM4EHSP90AA1HSP90AB1L3MBTL1PTK2
SCHEMBL19736359 0.82 CYP1A2 (0.51) KDM4EHSP90AA1HSP90AB1BRAFADORA3
SCHEMBL19706553 0.80 GLS (0.47) KDM4EHSP90AA1HSP90AB1L3MBTL1PTK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7605215-B2 Process for producing olefin copolymerization catalyst and process for producing olefin copolymer SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-10-20 US disclosed
US-20080227937-A1 Process for Producing Olefin Copolymerization Catalyst and Process for Producing Olefin Copolymer SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2008-09-18 US disclosed