Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | THPO | P40225 | 1/20 | 0.32 |
| ▸ | PPM1B | O75688 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.32 |
| ▸ | TFPI2 | P48307 | 1/20 | 0.32 |
| ▸ | PPP5C | P53041 | 1/20 | 0.32 |
| ▸ | PPP2CA | P67775 | 1/20 | 0.32 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GMNN | O75496 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9161453 | 0.63 | — | — | |
| SCHEMBL781958 | 0.63 | — | — | |
| SCHEMBL237697 | 0.63 | — | — | |
| SCHEMBL4163556 | 0.63 | TP53 (0.34) | TP53CYP3A4MAPK1HIF1ALMNA | |
| SCHEMBL2297883 | 0.62 | — | — | |
| SCHEMBL7637933 | 0.61 | — | — | |
| SCHEMBL8310241 | 0.60 | KDM4E (0.32) | TP53CYP3A4MAPK1HIF1ALMNA | |
| SCHEMBL6024806 | 0.60 | KDM4E (0.30) | KDM4E | |
| SCHEMBL11584532 | 0.60 | — | — | |
| SCHEMBL134403 | 0.60 | TSHR (0.41) | TP53CYP3A4MAPK1HIF1ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117715658-A | Method for inhibiting RAS | 锐新医药公司 | 2024-03-15 | — | — | CN | disclosed |
| CN-117683049-A | Indole derivatives as RAS inhibitors for the treatment of cancer | 锐新医药公司 | 2024-03-12 | — | — | CN | disclosed |
| CN-117616031-A | RAS inhibitors for the treatment of cancer | 锐新医药公司 | 2024-02-27 | — | — | CN | disclosed |
| CN-116457358-A | Indole derivatives as RAS inhibitors for the treatment of cancer | 锐新医药公司 | 2023-07-18 | — | — | CN | disclosed |
| CN-116209438-A | Treatment of malignant diseases with SHP2 mutations using SOS1 inhibitors | 锐新医药公司 | 2023-06-02 | — | — | CN | disclosed |
| WO-2020205537-A1 | COVALENT MODIFICATION AND CONTROLLED DELIVERY OF MU OPIOID RECEPTOR ANTAGONISTS | ALLEGHENY SINGER RESEARCH INSTITUTE (US) | 2020-10-08 | — | — | WO | disclosed |
| WO-2016132247-A1 | FLUORO-ALCOHOL ADDITIVES FOR ORIENTATION CONTROL OF BLOCK COPOLYMERS | INTERNATIONAL BUSINESS MACHINES CORPORATION (US) | 2016-08-25 | — | — | WO | disclosed |
| EP-0955957-A4 | IMPROVED POROUS BIOMATERIALS AND METHODS FOR THEIR MANUFACTURE | INTERPORE INTERNAT (US) | 2009-03-18 | — | — | EP | disclosed |
| EP-0955957-A1 | IMPROVED POROUS BIOMATERIALS AND METHODS FOR THEIR MANUFACTURE | INTERPORE INTERNATIONAL (US) | 1999-11-17 | — | — | EP | disclosed |
| WO-1997046178-A1 | IMPROVED POROUS BIOMATERIALS AND METHODS FOR THEIR MANUFACTURE | INTERPORE INTERNATIONAL (US) | 1997-12-11 | — | — | WO | disclosed |
| EP-0722445-A4 | DEGRADABLE POLYDIOXANEONE-BASED MATERIALS | BIOPAK TECHNOLOGY LTD (US) | 1997-04-02 | — | — | EP | disclosed |
| EP-0722445-A1 | DEGRADABLE POLYDIOXANEONE-BASED MATERIALS | Biopak Technology, Ltd. (US) | 1996-07-24 | — | — | EP | disclosed |
| WO-1995009164-A1 | DEGRADABLE POLYDIOXANEONE-BASED MATERIALS | BIOPAK TECHNOLOGY, LTD. (US) | 1995-04-06 | — | — | WO | disclosed |